Aspartam och säkerhet

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Aspartame consumption can cause mood disorders, mental stress, and depression. Maternal absorption of aspartame during pregnancy correlates with autism in children. Long-term aspartame use influences the cerebral and cerebellar cortex: it can cause neurodegeneration, modify the functions of neuronal cells, interrupt homeostasis, learning and memory.

Aspartame has been shown not to cause hypersensitivity even in a group of people with documented sensitivity. A few single cases have also been reported in which the withdrawal of aspartame-containing agents resulted in the disappearance of skin inflammation. In specific doses, aspartame appears to have analgesic and anti-inflammatory properties and it can contribute to the inhibition of ear inflammation caused by atopic dermatitis.

As an ingredient in many food products, aspartame, the metabolite of which is phenylalanine, is particularly harmful to people with phenylketonuria. During digestion, aspartame releases 50% of its mass in the form of phenylalanine, which leads to an increase in its level in the blood.

Although its genotoxicity is unknown, aspartame has elevated proliferation and slow apoptosis in test cells and could have carcinogenic properties. An increase in the markers Ki 67, PCNA and bcl-2 was noted. Studies on rats have found 200 mg/kg bodyweight to cause a significant increase in the markers c-myc, Ha-ras and the p53 suppressor gene. Exposure to aspartame from prenatal age, increases the incidence of lymphomas/leukemias in females. Studies have also confirmed an increase in P27 and H-ras expression. The relationship between aspartame and possible pancreatic, gastric, and endometrial cancer has not been proven.

Nutrients 2021, 13(6), 1957; Aspartame—True or False? Narrative Review of Safety Analysis of General Use in Products.

https://www.mdpi.com/2072-6643/13/6/1957/htm

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