Effekter av att överäta 1000 kcal vispgrädde per dag

[King Grub]

Background

High-fat diets (HFDs) have been linked to low-grade inflammation and insulin resistance.

Objective

The main purpose of the present study was to assess whether acute overfeeding with an HFD affects insulin sensitivity, gut barrier function, and fecal microbiota in humans.

Methods

In a prospective intervention study, 24 healthy men [mean ± SD: age 23.0 ± 2.8 y, body mass index (in kg/m2) 23.0 ± 2.1] received an HFD (48% of energy from fat) with an additional 1000 kcal/d (as whipping cream) above their calculated energy expenditure for 7 d. Insulin sensitivity (hyperinsulinemic euglycemic clamp), gut permeability (sugar and polyethylene glycol absorption tests, plasma zonulin), and gut microbiota profiles (high-throughput 16S rRNA gene sequencing) were assessed before and after overfeeding, and 14 d after intervention. Additionally, inflammation markers such as high-sensitivity C-reactive protein, lipopolysaccharide-binding protein, leptin, high-molecular-weight adiponectin, calprotectin, regulated on activation normal, T cell expressed and secreted (RANTES), and monocyte chemoattractant protein-1 were measured in plasma by ELISA. Finally, lipid parameters were analyzed in serum by a laboratory service.

Results

Although participants gained 0.9 ± 0.6 kg (P < 0.001) body weight, overnutrition was not associated with a significant change in insulin sensitivity (M value and glucose disposal). Overfeeding for 7 d resulted in elevated serum total (10.2%), LDL (14.6%) and HDL (14.8%) cholesterol concentrations (P < 0.01). In contrast, fasting plasma triglyceride significantly declined (29.3%) during overfeeding (P < 0.001). In addition, there were no significant changes in inflammatory markers. Urine excretion of 4 sugars and polyethylene glycol, used as a proxy for gut permeability, and plasma concentration of zonulin, a marker of paracellular gut permeability, were unchanged. Moreover, overfeeding was not associated with consistent changes in gut microbiota profiles, but marked alterations were observed in a subgroup of 6 individuals.

Conclusions

Our findings suggest that short-term overfeeding with an HFD does not significantly impair insulin sensitivity and gut permeability in normal-weight healthy men, and that changes in dominant communities of fecal bacteria occur only in certain individuals.

Short-Term Overfeeding with Dairy Cream Does Not Modify Gut Permeability, the Fecal Microbiota, or Glucose Metabolism in Young Healthy Men. The Journal of Nutrition, Volume 148, Issue 1, 1 January 2018, Pages 77–85.

[Diomedea exulans]

Bieffekt: Höjning av välmåendet med 10000 %.

Vräka i sig grädde och veta att det är för en god sak, drömlivet.

[King Grub]

Upp ett kilo i vikt. På ett par veckor hinner det inte att hända något med hälsan, men fortsätt med det i ett år så har du gått upp 50 kilo, och då blir det hälsoproblem av det i stället, oavsett vad man ätit för att åstadkomma uppgången. :p

[Omnomnom]

vispad eller ovispad?

[King Grub]

Det står inte om dom fick välja hur grädden skulle intas! Bara "whipping cream", inget om den var vispad eller inte.