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The purpose of this project was to further elucidate the effects post-exercise alcohol ingestion. This project had many novel aspects including using a resistance exercise (RE) only exercise design and the inclusion of women. Ten resistance trained men and nine resistance trained women completed two identical acute heavy resistance exercise trials (six sets of Smith machine squats) followed by ingestion of either alcohol or placebo. All participants completed both conditions. Prior to exercise (PRE) and three (+3h) and five (+5h) hours post exercise, muscle tissue samples were obtained from the vastus lateralis by biopsies. Muscle samples were analyzed for phosphorylated mTORC1, S6K1, and 4E-BP1. For men, there was a significant interaction effect for mTORC1 and S6K1 phosphorylation. At +3h, mTORC1 and S6K1 phosphorylation was higher for placebo than for alcohol. For women, there was a significant main effect for time. mTORC1 phosphorylation was higher at +3h than at PRE and at +5h. There were no significant effects found for 4E-BP1 phosphorylation in men or women. The major findings of this study was that although RE elicited similar mTORC1 signaling both in men and in women, alcohol ingestion appeared to only attenuate RE-induced phosphorylation of the mTORC1 signaling pathway in men. The present study provides evidence that alcohol should not be ingested following RE as this ingestion could potentially hamper the desired muscular adaptations to resistance exercise by reducing anabolic signaling, at least in men.
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J Strength Cond Res. 2016 Apr 21. Effect of Acute Alcohol Ingestion on Resistance Exercise Induced mTORC1 Signaling in Human Muscle.
2016-05-03, 08:02
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