Aminosyror och immunförsvar hos tränande

[King Grub]

Moderate and chronic bouts of exercise may lead to positive metabolic, molecular, and morphological adaptations, improving health. Although exercise training stimulates the production of reactive oxygen species (ROS), their overall intracellular concentration may not reach damaging levels due to enhancement of antioxidant responses. However, inadequate exercise training (i.e., single bout of high-intensity or excessive exercise) may result in oxidative stress, muscle fatigue and muscle injury. Moreover, during the recovery period, impaired immunity has been reported, for example; excessive-inflammation and compensatory immunosuppression. Nutritional supplements, sometimes referred to as immuno-nutrients, may be required to reduce immunosuppression and excessive inflammation. Herein, we discuss the action and the possible targets of key immuno-nutrients such as L-glutamine, L-arginine, branched chain amino acids (BCAA) and whey protein.

Immunonutrition for clinical applications to sports activities represents an emerging area for health, especially regarding supply of proteins and amino acids, since they are required for the optimal synthesis and concentration of a variety of immune related proteins (including cytokines and antibodies). Amino acids will feed into and impact on the regulation of key metabolic pathways in immune cells and the cellular oxidative stress response. At the anti-inflammatory molecular level, new findings have been reported such as enhancement of HSP levels, NO synthesis, and GSH/GSSG regulation, all essential for optimal immune function and recovery from intense periods of training.

Amino acid supplementation and impact on immune function in the context of exercise. Journal of the International Society of Sports Nutrition 14 December 2014.

http://www.jissn.com/content/pdf/s12970-014-0061-8.pdf