Citat:
Originally posted by nubi
Hur är det egentligen med insulinkänsligheten. Hur snabbt kan den förändras genom att ändra kosten och konditionsträning? Kan insulinkänsligheten sänkas permanent, eller är den "elastisk" ?
|
Den är inte permanent fixerad, utan den kan man ändra snabbt. Problemet för den stora allmänheten är väl att deras dåliga vanor är så inrutade.
TITLE: Modulation of insulin sensitivity by short-term exercise training
AUTHORS: F.L. Beaudoin, S. Chipkin, B. Braun
Insulin resistance (impaired insulin-mediated glucose uptake) is strongly associated with obesity and is the pathophysiology underlying Type-2 diabetes mellitus. Exercise training reduces insulin resistance, at least partially by enhancing peripheral (mainly skeletal muscle) sensitivity to insulin. There are several ways to measure insulin sensitivity but few that allow quantitative assessment of both hepatic and peripheral insulin sensitivity under physiological conditions. The continuous infusion with model assessment (CIGMA) is an innovative means of assessing insulin sensitivity based on mathematical modeling of the insulin-glucose feedback loop. PURPOSE: The purpose of this study was to determine if 5 days of exercise training would elicit a measurable change in insulin sensitivity. We hypothesized that short-term training would increase insulin sensitivity using the CIGMA method. METHODS: Nine sedentary, pre-menopausal women underwent a test of insulin sensitivity, followed by 5 days of moderate-intensity exercise training (65% of VO2max) designed to increase total daily energy expenditure by 20%. Twelve to 16 hours after the last bout of exercise, subjects repeated the test of insulin sensitivity. Plasma glucose and insulin responses were incorporated into a mathematical model to evaluate insulin sensitivity. Differences between treatment means pre- and post-training were evaluated by repeated measures ANOVA.
RESULTS: Compared to baseline values, fasting insulin and steady-state glucose and insulin concentrations were significantly lower following exercise training. The CIGMA coefficient of insulin sensitivity was also significantly lower post-training.