Det räcker med fastenivåer av insulin för maximal anabol stimulans av aminosyror.
Citat:
In conclusion, using AA-tRNA as the precursor pool, it is demonstrated that, in healthy humans in the postabsorptive state, insulin does not stimulate muscle protein synthesis
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Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E729-36.
Citat:
The amino acid simulation of anabolism is not dependent on the presence of insulin, IGF-1 (insulin-like growth factor-1) or growth hormone.
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Biochem Soc Trans. 2007 Nov;35(Pt 5):1302-5.
Citat:
if amino acids in amounts capable of causing a maximal response in protein synthesis are given, adding further insulin has no further stimulatory effect on protein synthesis.
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Exp Physiol. 2005 Jul;90(4):427-36.
Citat:
no rise in insulin availability is necessary for amino acids to stimulate leg (probably muscle) protein synthesis,
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Rennie et al, University of Nottingham (2004) J Physiol 558P, C10
Citat:
There appears to be a requirement for a minimal concentration of plasma insulin to stimulate muscle protein synthesis in response to resistance exercise and AA ingestion.
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Eur J Appl Physiol. 2005 May;94(1-2):1-10. Regulation of mTOR by amino acids and resistance exercise in skeletal muscle.
Citat:
At insulin of <5 muU/mL, AAs appear to stimulate MPS without increasing mTOR signaling. Further increasing availability of insulin to postprandial values increases signaling activity, but has no further effect on MPS.
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J Nutr. 2006 Jan;136(1):264S-8S.