Om man fortsätter använda kreatin när kroppens depåer är fulla börjar de sjunka igen, trots konstant påfylldnad.
”the elevation of TCr content of the human vastus lateralis was 22% (p < 0.05) after the one week loading phase (25 g/day) and
was reduced to 10% (n.s.) following 12 weeks of creatine supplementation (5 g/day), Thus, effect sizes after 12 weeks are markedly smaller than after 1–5 weeks, despite continued creatine supplementation"
"inhibition of protein synthesis by cycloheximide can prevent revent downregulation of creatine transport in L6 cells, suggesting that prolonged creatine exposure in vitro induces the synthesis of a protein that inhibits creatine transporter"
https://pubmed.ncbi.nlm.nih.gov/12546637/