Kaffe och levercancer

[King Grub]

BACKGROUND:

Coffee consumption has been reported to be inversely associated with hepatocellular carcinoma (HCC), the most common type of liver cancer. Caffeine has chemopreventive properties, but whether caffeine is responsible for the coffee-HCC association is not well studied. In addition, few studies have examined the relationship by sex, and no studies have examined whether there is an association between coffee and intrahepatic cholangiocarcinoma (ICC), the second most common type of liver cancer.

METHODS:

In the Liver Cancer Pooling Project, a consortium of U.S.-based cohort studies, data from 1,212,893 individuals (HCC n=860, ICC n=260) in nine cohorts were pooled. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression.

RESULTS:

Higher coffee consumption was associated with lower risk of HCC (HR>3 cups/day vs. non-drinker, 0.73; 95% CI, 0.53-0.99; ptrend cups/day=<0.0001). More notable reduced risk was seen among women than men (pinteraction=0.07). Women who consumed more than three cups of coffee per day were at a 54% lower risk of HCC (HR, 0.46; 95% CI, 0.26-0.81), whereas men had more modest reduced risk of HCC (HR, 0.93; 95% CI, 0.63-1.37). The associations were stronger for caffeinated coffee (HR>3 cups/day vs. non-drinker, 0.71, 95% CI, 0.50-1.01) than decaffeinated coffee (HR, 0.92; 95% CI, 0.55-1.54). There was no relationship between coffee consumption and ICC.

CONCLUSIONS:

These findings suggest that, in a U.S. population, coffee consumption is associated with reduced risk of HCC.

IMPACT:

Further research into specific coffee compounds and mechanisms that may account for these associations is needed.

Cancer Epidemiol Biomarkers Prev. 2015 Jun 30. Coffee consumption and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma by sex: The Liver Cancer Pooling Project.

[Shqypnia]

Kaffe (L) (K)

// Gammalt MSN språk

[upperkatt]

Gött, verkar ändå vara netto-positivt att dricka kaffe. Och gott är det också.

[Kognitivknug]

Jag tror att, utan tvekan, de flesta kaffedrickare inte hade övervägt att sluta dricka kaffe om en studie hade påvisat ett oräkneligt antal negativa effekter istället (här är även jag inkluderad). Det är helt enkelt livets dryck, från vaggan till graven.

Nu när ändå ett antal studier pekar på att kaffets inverkan är positiv på särskilda hälsoparametrar får man väl bara vara tacksam antar jag.

[LunaSpice]

Det har ju kommit stor, väldigt omfattande studie om inflammatoriska/anitinflammatoriska livsmedel där kaffe tillhör den antiinflammatoriska kategorin. Säkerligen har det med det att göra då många teorier tyder på att cancer generellt startar som en inflammation.

[Luca Brasi]

Effekten kan inte bero på att det är bättre att dricka kaffe än vodka till frukost?