Kolozzeum Forum - Sveriges största träningsforum
Gå tillbaka   Kolozzeum Forum - Sveriges största träningsforum > Träning > Kost & Näring

Svara
 
Ämnesverktyg Visningsalternativ
Gammal 2013-06-03, 21:59   #1
tjing
Banned User
 
Reg.datum: Jun 2012
Inlägg: 6 562
Njurfunktion efter tre olika dieter under 2 år.

Renal Function Following Three Distinct Weight Loss Dietary Strategies During 2 Years of Randomized Controlled Trial.
Citat:
Abstract:

OBJECTIVE: This study addressed the long-term effect of various diets, particularly low-carbohydrate high-protein, on renal function on participants with or without type 2 diabetes.

RESEARCH DESIGN AND METHODS: In the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT), 318 participants (age, 51 years; 86% men; BMI, 31 kg/m2; mean estimated glomerular filtration rate [eGFR], 70.5 mL/min/1.73 m2; mean urine microalbumin-to-creatinine ratio, 12:12) with serum creatinine <176 μmol/L (eGFR ≥30 mL/min/1.73 m2) were randomized to low-fat, Mediterranean, or low-carbohydrate diets. The 2-year compliance was 85%, and the proportion of protein intake significantly increased to 22% of energy only in the low-carbohydrate diet (P < 0.05 vs. low-fat and Mediterranean). We examined changes in urinary microalbumin and eGFR, estimated by Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration formulas.

RESULTS: Significant (P < 0.05 within groups) improvements in eGFR were achieved in low-carbohydrate (+5.3% [95% CI 2.1-8.5]), Mediterranean (+5.2% [3.0-7.4]), and low-fat diets (+4.0% [0.9-7.1]) with similar magnitude (P > 0.05) across diet groups. The increased eGFR was at least as prominent in participants with (+6.7%) or without (+4.5%) type 2 diabetes or those with lower baseline renal function of eGFR <60 mL/min/1.73 m2 (+7.1%) versus eGFR ≥60 mL/min/1.73 m2 (+3.7%). In a multivariable model adjusted for age, sex, diet-group, type 2 diabetes, use of ACE inhibitors, 2-year weight loss, and change in protein intake (confounders and univariate predictors), only a decrease in fasting insulin (β = -0.211; P = 0.004) and systolic blood pressure (β = -0.25; P < 0.001) were independently associated with increased eGFR. The urine microalbumin-to-creatinine ratio improved similarly across the diets, particularly among participants with baseline sex-adjusted microalbuminuria, with a mean change of -24.8 (P < 0.05).

CONCLUSIONS: A low-carbohydrate diet is as safe as Mediterranean or low-fat diets in preserving/improving renal function among moderately obese participants with or without type 2 diabetes, with baseline serum creatinine <176 μmol/L. Potential improvement is likely to be mediated by weight loss-induced improvements in insulin sensitivity and blood pressure.
Diabetes Care. 2013 May 20.

http://www.ncbi.nlm.nih.gov/pubmed/23690533
tjing är inte uppkopplad   Svara med citat
Gammal 2013-06-03, 22:04   #2
Rabiat
Registered User
 
Reg.datum: Aug 2012
Inlägg: 2 156
Undrar hur lång tid det tar för valda delar av detta att poppa upp i LCHF-kretsar. Där de valda delarna så klart är det som inte innehåller "low-carbohydrate, high protein".
Rabiat är inte uppkopplad   Svara med citat
Gammal 2013-06-03, 22:07   #3
tjing
Banned User
 
Reg.datum: Jun 2012
Inlägg: 6 562
Jag bara väntar på att den kommer upp på kostdoktorns sida.
tjing är inte uppkopplad   Svara med citat


Svara


Regler för att posta
Du får inte posta nya ämnen
Du får inte posta svar
Du får inte posta bifogade filer
Du får inte redigera dina inlägg

BB-kod är
Smilies är
[IMG]-kod är
HTML-kod är av

Forumhopp


Alla tider är GMT +1. Klockan är nu 15:25.


Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2025, Jelsoft Enterprises Ltd.
Svensk översättning av: Anders Pettersson
Copyright 2015, Kolozzeum (TM)