2013-06-03, 21:59
|
#1
|
Banned User
Reg.datum: Jun 2012
Inlägg: 6 562
|
Njurfunktion efter tre olika dieter under 2 år.
Renal Function Following Three Distinct Weight Loss Dietary Strategies During 2 Years of Randomized Controlled Trial.
Citat:
Abstract:
OBJECTIVE: This study addressed the long-term effect of various diets, particularly low-carbohydrate high-protein, on renal function on participants with or without type 2 diabetes.
RESEARCH DESIGN AND METHODS: In the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT), 318 participants (age, 51 years; 86% men; BMI, 31 kg/m2; mean estimated glomerular filtration rate [eGFR], 70.5 mL/min/1.73 m2; mean urine microalbumin-to-creatinine ratio, 12:12) with serum creatinine <176 μmol/L (eGFR ≥30 mL/min/1.73 m2) were randomized to low-fat, Mediterranean, or low-carbohydrate diets. The 2-year compliance was 85%, and the proportion of protein intake significantly increased to 22% of energy only in the low-carbohydrate diet (P < 0.05 vs. low-fat and Mediterranean). We examined changes in urinary microalbumin and eGFR, estimated by Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration formulas.
RESULTS: Significant (P < 0.05 within groups) improvements in eGFR were achieved in low-carbohydrate (+5.3% [95% CI 2.1-8.5]), Mediterranean (+5.2% [3.0-7.4]), and low-fat diets (+4.0% [0.9-7.1]) with similar magnitude (P > 0.05) across diet groups. The increased eGFR was at least as prominent in participants with (+6.7%) or without (+4.5%) type 2 diabetes or those with lower baseline renal function of eGFR <60 mL/min/1.73 m2 (+7.1%) versus eGFR ≥60 mL/min/1.73 m2 (+3.7%). In a multivariable model adjusted for age, sex, diet-group, type 2 diabetes, use of ACE inhibitors, 2-year weight loss, and change in protein intake (confounders and univariate predictors), only a decrease in fasting insulin (β = -0.211; P = 0.004) and systolic blood pressure (β = -0.25; P < 0.001) were independently associated with increased eGFR. The urine microalbumin-to-creatinine ratio improved similarly across the diets, particularly among participants with baseline sex-adjusted microalbuminuria, with a mean change of -24.8 (P < 0.05).
CONCLUSIONS: A low-carbohydrate diet is as safe as Mediterranean or low-fat diets in preserving/improving renal function among moderately obese participants with or without type 2 diabetes, with baseline serum creatinine <176 μmol/L. Potential improvement is likely to be mediated by weight loss-induced improvements in insulin sensitivity and blood pressure.
|
Diabetes Care. 2013 May 20.
http://www.ncbi.nlm.nih.gov/pubmed/23690533
|
|
|
2013-06-03, 22:04
|
#2
|
Registered User
Reg.datum: Aug 2012
Inlägg: 2 156
|
Undrar hur lång tid det tar för valda delar av detta att poppa upp i LCHF-kretsar. Där de valda delarna så klart är det som inte innehåller "low-carbohydrate, high protein".
|
|
|
2013-06-03, 22:07
|
#3
|
Banned User
Reg.datum: Jun 2012
Inlägg: 6 562
|
Jag bara väntar på att den kommer upp på kostdoktorns sida.
|
|
|
Regler för att posta
|
Du får inte posta nya ämnen
Du får inte posta svar
Du får inte posta bifogade filer
Du får inte redigera dina inlägg
HTML-kod är av
|
|
|
Alla tider är GMT +1. Klockan är nu 15:25.
|
    
|