Citat:
Originally posted by Castro
Är det verkligen vetenskapligt bevisat än?
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ALA ökar uttrycket av GLUT4kanaler på cellytorna. Eftersom GLUT4 transporterar in glukoset i cellerna så kommer detta leda till att glukoset snabbare kommer in i cellerna vilket i sin tur ger mindre insulinutsöndring.
Engagement of the Insulin-sensitive Pathway in the Stimulation of Glucose Transport by Alpha-lipoic Acid in 3T3-L1 Adipocytes.
Diabetologia 2000 (Mar); 43 (3): 294–303
Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A
RESULTS: Short-term treatment of 3T3-L1 adipocytes with R (+) alpha-lipoic acid rapidly stimulated glucose uptake in a wortmannin-sensitive manner, induced a redistribution of GLUT1 and GLUT4 to the plasma membrane, caused tyrosine phosphorylation of insulin receptor substrate-1 and of the insulin receptor, increased the antiphosphotyrosine-associated and insulin receptor substrate-1 associated phosphatidylinositol 3-kinase activity and stimulated Akt activity.
CONCLUSION/INTERPRETATION: These results indicate that R (+) alpha-lipoic acid directly activates lipid, tyrosine and serine/threonine kinases in target cells, which could lead to the stimulation of glucose uptake induced by this natural cofactor. These properties are unique among all agents currently used to lower glycaemia in animals and humans with diabetes.