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Glucose tolerance and body composition were determined in male rats given non-nutritive sweeteners (NNS) (aspartame or sucralose) in drinking water. AUC for glucose and insulin with NNS did not differ from control. NNS treatment had no effect on weight gain or percent body fat. Epididymal fat pad mass was higher with aspartame and the ratio of trunk to total fat was less with sucralose versus control, suggesting that NNS consumption altered body fat distribution.
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Appl Physiol Nutr Metab. 2017 Jul 10. THE EFFECT OF MODERATE CONSUMPTION OF NON-NUTRITIVE SWEETENERS ON GLUCOSE TOLERANCE AND BODY COMPOSITION IN RATS.
