Ibuprofen sänker testosteronet och krymper testiklarna

[Flem]

"Concern has been raised over increased male reproductive disorders in the Western world, and the disruption of male endocrinology has been suggested to play a central role. Several studies have shown that mild analgesics exposure during fetal life is associated with antiandrogenic effects and congenital malformations, but the effects on the adult man remain largely unknown. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. In the men, luteinizing hormone (LH) and ibuprofen plasma levels were positively correlated, and the testosterone/LH ratio decreased. Using adult testis explants exposed or not exposed to ibuprofen, we demonstrate that the endocrine capabilities from testicular Leydig and Sertoli cells, including testosterone production, were suppressed through transcriptional repression. This effect was also observed in a human steroidogenic cell line. Our data demonstrate that ibuprofen alters the endocrine system via selective transcriptional repression in the human testes, thereby inducing compensated hypogonadism." (Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789927/))

[Flem]

Ur en nyhetsartikel från 2015:

"1950s - Work starts to find a drug to treat rheumatoid arthritis that has no side-effects

1958 - After hundreds of compounds are made and screened for activity, a compound called BTS 8402 is given a clinical trial but it is found to be no better than aspirin

1961 - A patent is filed for the compound 2-(4-isobutylphenyl) propionic acid - later called ibuprofen

1966 - Clinical trials of ibuprofen take place in Edinburgh and its anti-inflammatory effect is seen in patients

1969 - Ibuprofen is launched in the UK on prescription only

1983 - Ibuprofen becomes available over the counter because of its safety record"


"An incredible 20,000 tonnes of ibuprofen are now made every year by a range of different companies under many different brand names. There are different forms of it too, including liquid forms specifically designed for children." (The hangover that led to the discovery of ibuprofen (https://www.bbc.com/news/health-34798438))

Tillväxtprognos:

"The global Ibuprofen market is expected to reach USD 687.77 million by 2023 at a CAGR [compound annual growth rate] of 2.1%." (Ibuprofen Market Research Report (https://straitsresearch.com/report/ibuprofen-market))

[Armed Dingo]

Reversibelt?

[jmk]

att hänga här reducerar testot, men testo är kanske inte allt när det kommer till fysik och livet heller,,, eller hur?

[Flem]

att hänga här reducerar testot, men testo är kanske inte allt när det kommer till fysik och livet heller,,, eller hur?
Tvärtom så har ens testosteron väldigt mycket med livet att göra. Det styr ens drift, motivation, hälsa, med mera. Ibuprofen påverkar alltså fostret när modern intar detta. Får modern inte i sig tillräckligt med vitamin D så påverkar även det fostrets utveckling, vilket kanske främst tycks ha en negativ inverkan på pojkar eftersom det påverkar utvecklingen av manliga karaktärsdrag.

[Sverker]

Under preparatet Iprensa finns tydlig information om graviditet och användning.
https://www.fass.se/LIF/product?userType=2&nplId=20091027000061

Den grupp av personer som jag själv träffat, och som är mest pålästa om olika läkemedel och effekter på barnet...är just gravida.

[Flem]

Under preparatet Iprensa finns tydlig information om graviditet och användning.
https://www.fass.se/LIF/product?userType=2&nplId=20091027000061

Den grupp av personer som jag själv träffat, och som är mest pålästa om olika läkemedel och effekter på barnet...är just gravida.
Ja, absolut. Gravida är mer hälsomedvetna. Och de gravida som faktiskt får i sig analgetika utgör bara en del i det pussel om att ge insikt i frågor som avvikande sexuella preferenser och könsdysfori.

[Kischen]

Använder sådant max en gång per år.