BCAA och Alzheimers

[King Grub]

INTRODUCTION:

High levels of plasmatic branched-chain amino acids (BCAA), commonly used as dietary supplements, are linked to metabolic risk factors for Alzheimer's disease (AD). BCAA directly influence amino acid transport to the brain and, therefore, neurotransmitter levels. We thus investigated the impact of BCAA on AD neuropathology in a mouse model.

METHODS:

3xTg-AD mice were fed either a control diet or a high-fat diet from 6 to 18 months of age. For the last 2 months, dietary BCAA content was adjusted to high (+50%), normal (+0%), or low (-50%).

RESULTS:

Mice fed a BCAA-supplemented high-fat diet displayed higher tau neuropathology and only four out of 13 survived. Mice on the low-BCAA diet showed higher threonine and tryptophan cortical levels while performing better on the novel object recognition task.

DISCUSSION:

These preclinical data underscore a potential risk of combining high-fat and high BCAA consumption, and possible benefits from BCAA restriction in AD.

Alzheimers Dement (N Y). 2018 Dec 10;4:677-687. Dietary intake of branched-chain amino acids in a mouse model of Alzheimer's disease: Effects on survival, behavior, and neuropathology

[Anders The Peak]

Conclusion
There is scientific evidence that dietary intervention can reduce the risk of developing age-related cognitive impairment or AD [3], [47]. Thus, nutritional strategies aimed at reducing AD pathology are of interest in the field. This study provides controlled preclinical data pinpointing the specific role of BCAA in an animal model of AD. For the first time, our results identify the potential risks of combining high BCAA consumption with a HFD, not only regarding peripheral toxicity but also with respect to the aggravation of AD-like tau neuropathology. On a more positive note, our results suggest that reducing the BCAA content in the diet supply, while maintaining protein intake, could have a beneficial effect on memory and could be considered in nutritional interventions aimed at improving cognitive performance and/or reducing the incidence of AD. Thus, it would be interesting to test whether protein supplementation with low BCAA concentration could prevent mood and memory impairment. Another easier intervention for the elderly would be to promote foods rich in protein but low in BCAA [36].
Conclusion (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290124/)

[Wrenchgirl]

Så... Det jag får fram är mer eller mindre skit i BCAA och satsa på fullvärdigt protein istället för hjärnans bästa?

[exevision]

Så... Det jag får fram är mer eller mindre skit i BCAA och satsa på fullvärdigt protein istället för hjärnans bästa?

Rent BCAA har alltid varit värdelöst, även när det gäller muskelbygge.

[Wrenchgirl]

Rent BCAA har alltid varit värdelöst, även när det gäller muskelbygge.

Värdelöst vet jag. Men att det nu till och med verkar vara skadligt. :p

[exevision]

Värdelöst vet jag. Men att det nu till och med verkar vara skadligt. :p

www.kolozzeum.com/forum/showthread.php?t=237140
www.kolozzeum.com/forum/showthread.php?t=233995

[Wrenchgirl]

www.kolozzeum.com/forum/showthread.php?t=237140
www.kolozzeum.com/forum/showthread.php?t=233995

Jo jag fick även en länk via en av alla träningssidor jag prenumererar på som menar på att BCAA till och med minskar resultaten på gymet mot att bara köra proteinpulver efter då det inte ger alla byggstenar samidigt som den upptar cellernas absorberingsförmåga så att istället för att ta till sig det fullvärdiga proteinet bearbetar kroppen det bcaa som du drack under passet lite på samma sätt at äter du kalciumrik mat samtidigt som järnrik så tar inte kroppen upp järnet.