HMB saknar effekt

[King Grub]

När deltagarna i studien inte får steroider samtidigt. :cool:

Leucine metabolites, α-hydroxyisocaproic acid (α-HICA) and β-hydroxy-β-methylbutyrate (calcium, HMB-Ca and free acid, HMB-FA), have been proposed to augment resistance training-induced changes in body composition and performance.

PURPOSE

We aimed to conduct a double-blind randomized controlled pragmatic trial to evaluate the effects of off-the-shelf leucine metabolite supplements of α-HICA, HMB-FA and HMB-Ca, on resistance training-induced changes in muscle thickness, and performance.

METHODS

Forty men were randomly assigned to receive α-HICA (n=10, fat-free mass [FFM]=62.0 ± 7.1 kg), HMB-FA (n=11, FFM=62.7 ± 10.5 kg), HMB-Ca (n=9, FFM=65.6 ± 10.1 kg), or placebo (PLA; n=10, FFM=64.2 ± 5.7 kg). The training program consisted of whole body thrice weekly resistance training for 8wk (7 exercises/session, 3–4 sets per session, at 70-80% 1RM). Skeletal muscle thickness by ultrasound, performance measures, and blood measures (creatine kinase [CK], insulin-like growth factor 1 [IGF-1], growth hormone [GH], cortisol and total testosterone) were evaluated at baseline and at the end of weeks 4 and 8.

RESULTS

Time-dependent changes were observed for muscle thickness (p < 0.001), 1RM bench press and squat (p < 0.001), Wingate peak power (p = 0.02), countermovement jump height (p = 0.03), power (p = 0.006), CK, IGF-1, GH, and cortisol (all p <0.001). No significant between-group or time-by-group interactions were observed.

CONCLUSION

No leucine metabolite resulted in any ergogenic effects on any outcome variable. Supplementation with leucine metabolites – α-HICA, HMB-FA, or HMB-Ca – is not a supplementation strategy that improves muscle growth and strength development in young adult men.

Leucine Metabolites Do Not Enhance Training-induced Performance or Muscle Thickness. Medicine & Science in Sports & Exercise: August 10, 2018.

[Kartoffelsalat]

Bra det är ju både dyrt och äckligt.

[Max]

Bra det är ju både dyrt och äckligt.
Då måste det ju "funka"

[Sheogorath]

Käkar upp min sista burk och sen får det vara slut. :thumbup:

[Lillleif]

Dags att stänga den där 109 sidor långa tråden om HMB som startade 2008 då? :p

[King Grub]

Ingestion of proteins with high leucine content during resistance training (RT) can augment hypertrophy. Some data suggest that a leucine metabolite, β-hydroxy, β-methylbutyrate (HMB), is substantially more anabolically efficacious than leucine.

Purpose

We aimed to test whether supplementation with HMB versus leucine, added to whey protein, would result in differential muscle hypertrophy and strength gains in young men performing resistance training.

Methods

Twenty-six resistance-trained men (23 ± 2 y) performed 12 wk of RT with 3 phases. Phase 1: 8 wk of periodized RT (3 training sessions/wk). Phase 2: 2 wk overreaching period (5 sessions/wk). Phase 3: 2 wk taper (3 sessions/wk). Participants were randomly assigned to twice daily ingestion of: whey protein (25 g) plus HMB (1.5 g) (Whey+HMB; n=13) or whey protein (25 g) plus leucine (1.5 g) (Whey+Leu; n=13). Skeletal muscle biopsies were performed before and after RT. Measures of fat and bone-free mass (FBFM), vastus lateralis (VL) muscle thickness and muscle cross-sectional area (CSA – both by ultrasound), muscle fiber CSA, and 1-repetition maximum (1-RM) strength tests were determined.

Results

We observed increases in FBFM, VL muscle thickness, muscle CSA and fiber type CSA and 1-RM strength with no differences between groups at any phase. We observed no differences between groups or time-by-group interactions in hormone concentrations at any phase of the RT program.

Conclusion

HMB added to whey did not result in greater increases in any measure of muscle mass, strength, or hormonal concentration compared to leucine added to whey. Our results show that HMB is no more effective in stimulating RT-induced hypertrophy and strength gains than leucine.

Equivalent Hypertrophy and Strength Gains in HMB- or Leucine-supplemented Men. Medicine & Science in Sports & Exercise: August 15, 2018.

[King Grub]

HMB minskar inte muskelnedbrytning heller.

This study was a randomised, double-blind, placebo-controlled cross-over trial examining the effects of β-hydroxy β-methylbutyrate free acid (HMB-FA) supplementation on muscle protein breakdown, cortisol, testosterone and resting energy expenditure (REE) during acute fasting. Conditions consisted of supplementation with 3 g/d HMB-FA or placebo during a 3-d meat-free diet followed by a 24-h fast. Urine was collected before and during the 24-h fast for analysis of 3-methylhistidine:creatinine ratio (3MH:CR). Salivary cortisol, testosterone, their ratio (T:C), and the cortisol awakening response were assessed. ANOVA was used to analyse all dependent variables, and linear mixed models were used to confirm the absence of carryover effects. Eleven participants (six females, five males) completed the study. Urinary HMB concentrations confirmed compliance with supplementation. 3MH:CR was unaffected by fasting and supplementation, but the cortisol awakening response differed between conditions. In both conditions, cortisol increased from awakening to 30 min post-awakening (P=0·01). Cortisol was reduced from 30 to 45 min post-awakening with HMB-FA (−32 %, d=−1·0, P=0·04), but not placebo (PL) (−6 %, d=−0·2, P=0·14). In males, T:C increased from 0 to 24 h of fasting with HMB-FA (+162 %, d=3·0, P=0·001), but not placebo (+13 %, d=0·4, P=0·60), due to reductions in cortisol. REE was higher at 24 h of fasting than 16 h of fasting independent of supplementation (+4·0 %, d=0·3, P=0·04). In conclusion, HMB-FA may affect cortisol responses, but not myofibrillar proteolysis, during acute 24-h fasting.

β-Hydroxy β-methylbutyrate free acid alters cortisol responses, but not myofibrillar proteolysis, during a 24-h fast. British Journal of Nutrition, Volume 119, Issue 5 14 March 2018 , pp. 517-526.

[meow]

Funkar den som placebo då?

[poppen11]

Funkar den som placebo då?

Hehe, bra fråga! Hypotes: funkar sämre på dem som postat i denna tråd än ett slumpmässigt urval från instagram:naughty:

[Agitator]

Provade HMB förra året några intag. Nej det var ingen höjdare, visst det gick att få ner rakt i munnen och sedan med vatten eller lösa upp i ett glas med vatten eller smaksätta det. Men det var fan inte värt allt strul och ej tillfredställande smakmässigt. Kände mig oftast lite orolig i magen efter intaget en stund och ibland kändes efter smaken bara knasig.

Så la ner HMB direkt, har nog 80 procent av påsen kvar hemma. Den slängs nästa gång jag röjer lite. Var inget fan alls av den produkten oavsett hur mycket folk hypande den på diverse forum.

Det räcker med träna och vara lite envissamt koffein.

[Lazius]

Jag har prövat det i omgångar genom åren (skam den som ger sig *screwy* ), men har aldrig märkt något positivt vad gäller styrka, uthållighet eller muskelvolym... Kommer aldrig testa det igen!

[Shqypnia]

Det faktum att det smakar skit är nog den stora bidragande orsaken till varför folk tror på den.

[Sheogorath]

Förstår fortfarande inte varför folk inte bara köpte kapslar. Klart det är dyrare, men inte dyrt. Om det nu är så vidrigt.

[Don H]

Förstår fortfarande inte varför folk inte bara köpte kapslar. Klart det är dyrare, men inte dyrt. Om det nu är så vidrigt.

Förmodligen samma fenomen som gäller med EAA, många gnäller över smaken, men köper inte kapslar.
Man måste lida lite för att det skall ge något

[bertbert]

Okej, ingen "det funkar för mig" än? Kolo har verkligen trappat ner ett par växlar! :)

[tramadol]

Köpte hmi för runt 500kr. Ingen aning om det hjälpte ett skit, tror inte det. Men gillar att testa nya kosttillskott så ingen fara skedd^^

[King Grub]

Age-related sarcopenia and dynapenia are associated with frailty and metabolic diseases. Resistance exercise training (RET) adjuvant to evidence-based nutritional intervention(s) have been shown as mitigating strategies. Given that HMB supplementation during RET improves lean body mass in younger humans (Wilson et al., 2014), and that we have shown that HMB acutely stimulates muscle protein synthesis (MPS) and inhibits breakdown; we hypothesized that chronic supplementation of HMB adjuvant to RET would enhance MPS and muscle mass/function in older people.We recruited 16 healthy older men (PLA: 68.5±1.0y, HMB: 67.8±1.1y) for a randomised double-blind-placebo (PLA) controlled trial (HMB 3 x 1g/day vs. PLA) involving a 6-week unilateral progressive RET regime (6 x 8 repetitions, 75% 1-RM, 3.wk-1). D2O dosing was performed over the first two weeks (0-2w) and last two weeks (4-6w) with bilateral vastus lateralis (VL) biopsies at 0-2 and 4-6 weeks (each time 75±2 min after a single bout of RE) for quantification of early and later MPS responses and post-RE myogenic gene expression. Thigh lean mass was measured by DXA, VL thickness and architecture (fibre length and pennation angle) by ultrasound at 0/3/6 weeks, and strength by knee extensor 1-RM testing and MVC by isokinetic dynamometry (approx. every 10 days). RET induced strength increases (1-RM) in the exercised leg in both groups (398±22N to 499±30N HMB vs. 396±29N to 510±43N PLA (both P<0.05)). In addition, MVC also increased (179±12Nm to 203±12Nm HMB vs. 185±10Nm to 217±11Nm PLA (both P<0.05); there were no group differences. Muscle thickness of the VL increased significantly in the exercised leg in both groups, with no group differences. Thigh lean mass (by DXA) rose to significance only in the HMB group (by 5.8% to 5734±245g p=0.015 vs. 3.0% to 5644±323g P=0.06 in PLA). Interestingly, while MPS remained unchanged in the UT legs of both groups between 0-2 weeks e.g. ∼1.10 ±0.07%.d-1 (HMB) and 1.12±0.07%.d-1(PLA), the trained leg (T) exhibited increased MPS in the HMB group only at 0-2-weeks (1.42±0.10%.d-1, P<0.05) compared with untrained leg (UT): but was not different at 4-6-weeks: 1.27±0.05%.d-1. However, there were no significant differences in MPS between the HMB and PLA groups at any given time point.

We also observed significant inductions of c-Myc gene expression following each acute RE bout, with no group differences, with no changes in other muscle atrophy/hypertrophy or myogenic transcription factor genes we measured. RET with adjuvant HMB supplements in free-living healthy older men did not enhance muscle strength or mass significantly, over that of RET alone (PLA), despite enhancing MPS over the first two weeks. Longer and larger studies are needed to determine the potential effects of HMB supplementation; translating to any functional benefit.

A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clinical Nutrition, 27 September 2018.