King Grub
2018-06-20, 10:59
The storage of lipids as triglycerides (TG) and the de novo synthesis (lipogenesis) of fatty acids from non-lipid precursors (DNL) are important functions of adipose tissue (AT) that influence whole body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kinetics in humans. Fifty-two women with obesity (27 African-Americans; 25 Caucasians; 29.7 ± 5.5 years; BMI 32.2 ± 2.8 kg/m2; 44.3 ± 4.0% body fat) were enrolled in the study. In vivo synthesis (or replacement) of triglycerides (fTG) and the synthesis of the fatty acid palmitate (measure of adipose de novo lipogenesis (fDNL)) were assessed using an 8-week incorporation of deuterium (2H) into lipids (glycerol and palmitate moieties of TGs) in subcutaneous abdominal (scABD) and femoral (scFEM) AT. We report significant race differences in TG synthesis and DNL, with Caucasians having higher fTG and fDNL than African-Americans. The DNL contribution to newly synthesized TG (corrected fDNL) was not different between races. Interestingly, our findings show that the scFEM depot had higher TG replacement rates than the scABD. Finally, the fTG was negatively correlated with changes in body weight. Our results provide the first evidence that in vivo TG replacement rates differ by ethnicity. In addition, TG turnover varies by depot location in humans, implying an increased capacity for TG storage and higher lipolysis in the scFEM AT.
J Lipid Res. 2018 Jun 17. Racial differences in in vivo adipose lipid kinetics in humans.
J Lipid Res. 2018 Jun 17. Racial differences in in vivo adipose lipid kinetics in humans.