BCAA och diabetes

[King Grub]

The branched chain amino acids (BCAA) have increasingly been studied as playing a role in diabetes, with the PubMed search string "diabetes AND "branched chain amino acids"" showing particular growth in studies of the topic over the past decade

J Diabetes. 2018 Jan 25. Diabetes and branched chain amino acids: What is the link?

http://docdro.id/G75zWrP

[Shqypnia]

Haha snart är BCAA i samma klass som rökning. Förhoppningsvis dör hajpen ut snart.

#diebitchdie

[Max]

Haha snart är BCAA i samma klass som rökning. Förhoppningsvis dör hajpen ut snart.

#diebitchdieVassle är rikt på BCAA, exempelvis. Studierna som vaskas fram _tror_ jag inte syftar på BCAA-tillskott, utan på halten BCAA i kosten överlag.

[King Grub]

Vid kaloribalans eller underskott utövar BCAA företrädesvis positiva metabola effekter, men vid kaloriöverskott förlorar cellerna förmågan att bryta ned och ta hand om BCAA.

Branched-chain amino acids (BCAAs) appear to influence several synthetic and catabolic cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most notably known to increase protein synthesis through modulating protein translation, explaining their appeal to resistance and endurance athletes for muscle hypertrophy, expedited recovery, and preservation of lean body mass. In addition to anabolic effects, BCAAs may increase mitochondrial content in skeletal muscle and adipocytes, possibly enhancing oxidative capacity. However, elevated circulating BCAA levels have been correlated with severity of insulin resistance. It is hypothesized that elevated circulating BCAAs observed in insulin resistance may result from dysregulated BCAA degradation. This review summarizes original reports that investigated the ability of BCAAs to alter glucose uptake in consequential cell types and experimental models. The review also discusses the interplay of BCAAs with other metabolic factors, and the role of excess lipid (and possibly energy excess) in the dysregulation of BCAA catabolism. Lastly, this article provides a working hypothesis of the mechanism(s) by which lipids may contribute to altered BCAA catabolism which often accompanies metabolic disease.

Mol Nutr Food Res. 2018 Jan 29. BCAA Metabolism and Insulin Sensitivity - Dysregulated by Metabolic Status?

http://docdro.id/xo0C0bR

[King Grub]

BACKGROUND:

Circulating branched-chain amino acids (BCAAs; isoleucine, leucine, valine) are consistently associated with increased type 2 diabetes (T2D) risk, but the relationship with dietary intake of BCAAs is less clear.

METHODS:

The longitudinal Nurses' Health Study II cohort conducted a blood collection from 1996 to 1999. We profiled plasma metabolites among 172 incident T2D cases and 175 age-matched controls from women reporting a history of gestational diabetes before blood draw. We estimated dietary energy-adjusted BCAAs from food frequency questionnaires. We used conditional logistic regression models to estimate odds ratios (OR) and 95% CI of T2D risk across quartiles (Q1-Q4) of BCAAs, adjusting for age, body mass index (BMI), physical activity, family history, and other established risk factors. We also assessed joint exposure to below/above medians of diet and plasma concentrations, with lower diet/lower plasma as reference.

RESULTS:

Dietary and plasma BCAA concentrations were positively associated with incident T2D (diet Q4 vs Q1 OR = 4.6, CI = 1.6, 13.4; plasma Q4 vs Q1 OR = 4.4, CI = 1.4, 13.4). Modeling the joint association indicated that higher diet BCAAs were associated with T2D when plasma concentrations were also higher (OR = 6.0, CI = 2.1, 17.2) but not when concentrations were lower (OR = 1.6, CI = 0.61, 4.1). Conversely, higher plasma BCAAs were associated with increased T2D for either lower or higher diet.

CONCLUSIONS:

Independent of BMI and other risk factors, higher diet and plasma BCAA concentrations were associated with an increased incident T2D risk among high-risk women with a history of gestational diabetes, supporting impaired BCAA metabolism as conferring T2D risk.

Clin Chem. 2018 Jun 26. Dietary Intakes and Circulating Concentrations of Branched-Chain Amino Acids in Relation to Incident Type 2 Diabetes Risk Among High-Risk Women with a History of Gestational Diabetes Mellitus.

[xan]

Vid kaloribalans eller underskott utövar BCAA företrädesvis positiva metabola effekter, men vid kaloriöverskott förlorar cellerna förmågan att bryta ned och ta hand om BCAA.



Mol Nutr Food Res. 2018 Jan 29. BCAA Metabolism and Insulin Sensitivity - Dysregulated by Metabolic Status?

http://docdro.id/xo0C0bR

TLDR - Ät er inte feta bara för att ni lyfter vikter.