Kreatin och cancer

[King Grub]

Creatine supplementation has been associated with increased cancer risk. In fact, there is evidence indicating that creatine and/or creatinine are important precursors of carcinogenic heterocyclic amines (HCAs). The present study aimed to investigate the acute and chronic effects of low- and high-dose creatine supplementation on the formation of carcinogenic HCAs (i.e., PhIP, 8-MeIQx, IFP, and 4,8-DiMeIQx) in healthy humans. This was a non-counterbalanced single-blind crossover study divided in two phases, in which low- and high-dose creatine protocols were tested. After acute (1 day) and chronic supplementation (30 days), the HCAs 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-MeIQx), 2-amino-(1,6-dimethylfuro[3,2-e]imidazo[4,5-b])pyridine (IFP) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) were assessed through a newly developed HPLC–MS/MS method. Dietary HCAs intake and blood and urinary creatinine were also evaluated. Out of 576 assessments performed (from 149 urine samples), only 9 (3 from creatine and 6 from placebo) showed quantifiable levels of HCAs (8-MeIQx: n = 3; 4,8-DiMeIQx: n = 2; PhIP: n = 4). Individual analyses revealed that diet rather than creatine supplementation was the main responsible factor for HCA formation in these cases. This study provides compelling evidence that both low and high doses of creatine supplementation, given either acutely or chronically, did not cause increases in the carcinogenic HCAs PhIP, 8-MeIQx, IFP, 4,8-DiMeIQx in healthy subjects. These findings challenge the long-existing notion that creatine supplementation could potentially increase the risk of cancer by stimulating the formation of these mutagens.

Can creatine supplementation form carcinogenic heterocyclic amines in humans? J Physiol. 2015 Jul 6.

http://onlinelibrary.wiley.com/doi/10.1113/JP270861/pdf

[Klein]

Can creatine supplementation form carcinogenic heterocyclic amines in humans? J Physiol. 2015 Jul 6.

http://onlinelibrary.wiley.com/doi/10.1113/JP270861/pdf

Självklart är det så eftersom de mutagena ämnena skapas när kreatinin upphettas signifikant vilket bara sker vid matlagning, inte supplementering med kreatin.

[TomasB]

Självklart är det så eftersom de mutagena ämnena skapas när kreatinin upphettas signifikant vilket bara sker vid matlagning, inte supplementering med kreatin.

Vilka är de mutagena ämnena som skapas? (ifrågasätter inte, är bara nyfiken).

[Klein]

Vilka är de mutagena ämnena som skapas? (ifrågasätter inte, är bara nyfiken).

Du kan ju googla. Heterocykliska aminer såsom:

2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
2-amino-1,5,6-trimethylimidazo[4,5-b]pyridine (TMIP)

[Sverker]

Kunde inte låta bli att söka. Hittade denna som beskriver ganska bra förloppet när mutagnerna bildas
https://books.google.se/books?id=CqEbnfxdHXQC&pg=PA403&lpg=PA403&dq=2-Amino-3,8-dimethylimidazo+creatinin&source=bl&ots=jIw_zinZpT&sig=BHn9MF7ZAEsusS08L9AYRoAwRCE&hl=sv&sa=X&ei=yEadVbLCOKH6ygO6jLC4Cg&ved=0CC0Q6AEwAzgK#v=onepage&q=2-Amino-3%2C8-dimethylimidazo%20creatinin&f=false

Verkar vara rätt höga stektemperaturer, > 200 grader C vilket ger ( kraftig brunfärgning på smöret i stekpannan och ) mutagen brunfärgning på köttets yta.

Ska söka i helgen hur mildare stekning vid 170 - 175 grader C påverkar...måste finnas något på nätet om det:d