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King Grub
2014-11-06, 12:28
Background:

Fat accumulation in nonadipose tissue is linked to insulin resistance and metabolic diseases. Earlier studies have shown that hepatic lipid accumulation can occur after 4 d of a high-fat diet in humans, and this fat accumulation can be blunted by the ingestion of additional proteins.

Objectives:

In this study, we explored whether a single high-fat meal increased the lipid content in liver and skeletal muscle as measured by using in vivo proton magnetic resonance spectroscopy (1H-MRS) and whether the addition of protein can modulate the postprandial ectopic lipid storage.

Design:

Intrahepatic lipid (IHL) and intramyocellular lipid (IMCL) concentrations were determined by using 1H-MRS before and 3 and 5 h after a high-fat with added protein meal (61.% of energy from fat) or a high-fat without added protein meal (mean ± SEM: 51.1 ± 7.9 g of protein; 191.9 ± 9.9 kcal added) in a randomized crossover study. IHL and IMCL concentrations were converted to absolute concentrations (g/kg wet weight) by using water as an internal reference.

Results:

Nine lean, healthy subjects [6 men and 3 women; mean (±SD) age: 22.7 ± 3.0 y; mean body mass index (in kg/m2): 21.8 ± 1.8] were included in this study. IHL concentrations were increased ∼20% (P < 0.01) at 3 h after the meal and did not further increase after 5 h. In contrast, IMCL concentrations were not altered during the postprandial period (P = 0.74). The addition of protein to a single high-fat meal did not change the postprandial accumulation of fat in the liver (P = 0.93) or skeletal muscle (P = 0.84).

Conclusions:

In this study, we showed that a single energy-dense, high-fat meal induced the net lipid accumulation in the liver, which was detected by using in vivo 1H-MRS. This noninvasive approach might bring new opportunities to study postprandial hepatic lipid dynamics. The addition of protein did not change the ectopic lipid retention after a single high-fat meal.


Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein. Am J Clin Nutr November 5, 2014.

http://ajcn.nutrition.org/content/early/2014/11/05/ajcn.114.094730.full.pdf+html

maqan
2014-11-06, 20:23
Så länge personerna inte överäter i övrigt bör väl ansamlingen av fett inte vara något problem eftersom de kommer att förbruka fettet mellan måltider.

Fartman
2014-11-07, 01:27
Är väl ingen nyhet att man får rätt kraftig fettinlagring i levern efter mycket fet mat? Jag fick då lära mig det redan på grundnivå. Har för mig att man även brukar ha mycket fett lagrat i levern efter en rejäl fylla.
Men grejen är ju den att fettet inte stannar där för alltid utan frisätts ut i blodet igen "vid behov".

maqan
2014-11-07, 20:27
Men grejen är ju den att fettet inte stannar där för alltid utan frisätts ut i blodet igen "vid behov".

Ja, därför bör det inte vara några problem såvida man inte befinner sig på energiöverskott.