King Grub
2012-11-28, 11:43
AIM:
This study aimed to investigate the effects of vitamin C administration on skeletal muscle hypertrophy induced by mechanical overload in rats.
METHODS:
Male Wistar rats were randomly assigned to 3 groups: 1) sham-operated group (n = 8), 2) placebo-administered group (n = 8), and 3) vitamin C-administered group (n = 8). In the placebo-administered and vitamin C-administered groups, the gastrocnemius and soleus muscles of the right hindlimb were surgically removed to overload the plantaris muscle. Vitamin C (500 mg·kg(-1) ) was orally administered to the vitamin C-administered group once a day for 14 days.
RESULTS:
Synergist muscle ablation caused significant increases in wet weight and protein concentration of the plantaris muscle in both the placebo-administered (P < 0.01) and vitamin C-administered groups (P < 0.01) compared with the sham-operated group. However, the magnitude of plantaris muscle hypertrophy (expressed as a percentage of the contralateral plantaris muscle) was significantly smaller (P < 0.01) in the vitamin C-administered group (141%) than in the placebo-administered group (152%). Compared with the sham-operated group, only the placebo-administered group showed higher expressions of phosphorylated p70s6k and Erk1/2 (positive regulators of muscle protein synthesis), and a lower expression of atrogin-1 (a muscle atrophy marker). Concentrations of vitamin C and oxidative stress markers in the overloaded muscle were similar between the placebo-administered and vitamin C-administered groups.
CONCLUSION:
Oral vitamin C administration can attenuate overload-induced skeletal muscle hypertrophy, which may have implications for antioxidant supplementation during exercise training
Acta Physiol (Oxf). 2012 Nov 26. Vitamin C administration attenuates overload-induced skeletal muscle hypertrophy in rats.
This study aimed to investigate the effects of vitamin C administration on skeletal muscle hypertrophy induced by mechanical overload in rats.
METHODS:
Male Wistar rats were randomly assigned to 3 groups: 1) sham-operated group (n = 8), 2) placebo-administered group (n = 8), and 3) vitamin C-administered group (n = 8). In the placebo-administered and vitamin C-administered groups, the gastrocnemius and soleus muscles of the right hindlimb were surgically removed to overload the plantaris muscle. Vitamin C (500 mg·kg(-1) ) was orally administered to the vitamin C-administered group once a day for 14 days.
RESULTS:
Synergist muscle ablation caused significant increases in wet weight and protein concentration of the plantaris muscle in both the placebo-administered (P < 0.01) and vitamin C-administered groups (P < 0.01) compared with the sham-operated group. However, the magnitude of plantaris muscle hypertrophy (expressed as a percentage of the contralateral plantaris muscle) was significantly smaller (P < 0.01) in the vitamin C-administered group (141%) than in the placebo-administered group (152%). Compared with the sham-operated group, only the placebo-administered group showed higher expressions of phosphorylated p70s6k and Erk1/2 (positive regulators of muscle protein synthesis), and a lower expression of atrogin-1 (a muscle atrophy marker). Concentrations of vitamin C and oxidative stress markers in the overloaded muscle were similar between the placebo-administered and vitamin C-administered groups.
CONCLUSION:
Oral vitamin C administration can attenuate overload-induced skeletal muscle hypertrophy, which may have implications for antioxidant supplementation during exercise training
Acta Physiol (Oxf). 2012 Nov 26. Vitamin C administration attenuates overload-induced skeletal muscle hypertrophy in rats.