Kurkumin undertrycker fettbildning

[King Grub]

Curcumin is a well-known component of the cook seasoning and traditional herb turmeric (Curcuma longa), which has been reported to prevent obesity. However, the mechanism still remains to be determined. In this study, curcumin is found to be an effective inhibitor of fatty acid synthase (FAS), and its effects on adipocytes are further evaluated. Curcumin shows both fast-binding and slow-binding inhibitions to FAS. Curcumin inhibits FAS with an IC(50) value of 26.8 μM, noncompetitively with respect to NADPH, and partially competitively against both substrates acetyl-CoA and malonyl-CoA. This suggests that the malonyl/acetyl transferase domain of FAS possibly is the main target of curcumin. The time-dependent inactivation shows that curcumin inactivates FAS with two-step irreversible inhibition, a specific reversible binding followed by an irreversible modification by curcumin. Like other classic FAS inhibitors, curcumin prevents the differentiation of 3T3-L1 cells, and thus represses lipid accumulation. In the meantime, curcumin decreases the expression of FAS, down-regulates the mRNA level of PPARγ and CD36 during adipocyte differentiation. Curcumin is reported here as a novel FAS inhibitor, and it suppresses adipocyte differentiation and lipid accumulation, which is associated with its inhibition of FAS. Hence, curcumin is considered to be having potential application in the prevention of obesity.

Mol Cell Biochem. 2011 Jan 9. Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin.

[Pansartax]

Och senap som är så gott!

Edit: Curry kanske är en bättre källa.

[Ola Wallengren]

Utifrån sammanfattningen så tolkar jag detta som resultat av cellstudier.
Vad detta skulle innebära för energibalans och fettinlagring hos människa verkar alltså bara vara spekulativt så här långt.

[Sk1llz]

Edit: Curry kanske är en bättre källa.

Och Gurkmeja en ännu bättre :)

[Sverker]

Stoppar alltså byggandet av fettsyror i fettcellerna. Hur stor är den produktionen ? Kan inte vara mycket glukos som tas upp i fettvävnaden.


Den stora frågan på Kollo måste vara ifall fettsyrasyntetaset i levern också blockeras. Fruktosskräcken alltså:D

[r3mpuh]

Tack för posten King Grub!

Vore intressant med framtida studier på människor. :p

[Eddie Vedder]

Curcumin är annars väldigt studerat för att eventuellt kunna förebygga Alzheimers. Dels baserat på potentiella fysiologiska effekter men även baserat på det faktum att indier uppvisar lägre incidens i Alzheimers:

There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer’s disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small short-term studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.

[...]

It has been demonstrated in various experimental preparations to have anti-oxidant, anti-inflammatory, and cholesterol-lowering properties (see below), all three of which are felt to be key processes involved in the pathogenesis of Alzheimer’s disease (AD). Epidemiological studies in India, a country where turmeric consumption is widespread, suggest it has one of the lowest prevalence rates of AD in the world(6, 7). Though there are many potential explanations for this observation, a preventative role of curcumin is a possibility. In this paper we summarize the evidence supporting the evaluation of a role for curcumin in the prevention and treatment of human AD.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702408/

A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease. Curr Alzheimer Res. Author manuscript; available in PMC 2006 December 15.

Det finns även teorier om att det kan vara cancerpreventivt:

Abstract
Chemoprevention, which is referred to as the use of nontoxic natural or synthetic chemicals to intervene in multistage carcinogenesis, has emerged as a promising and pragmatic medical approach to reduce the risk of cancer. Numerous components of edible plants, collectively termed “phytochemicals” have been reported to possess substantial chemopreventive properties. Curcumin, a yellow coloring ingredient derived from Curcuma longa L. (Zingiberaceae), is one of the most extensively investigated and well-defined chemopreventive phytochemicals. Curcumin has been shown to protect against skin, oral, intestinal, and colon carcinogenesis and also to suppress angiogenesis and metastasis in a variety animal tumor models.

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Advances in Experimental Medicine and Biology, 2007, Volume 595, 149-172

[skaparn]

Kurkumin - det nya kanel

[RassK]

Vad använder man kurkumin till? Maträtter osv.

[Crocker]

Vad använder man kurkumin till? Maträtter osv.
Gurkmeja ex. färga, funkar bra till ris,omelett,nudlar bl.a.

[r3mpuh]

Nu är frågan hur mycket gurkmeja man ska inta per dag. ;)

[Eddie Vedder]

En sak man alltid måste ha i åtanke när det kommer resultatet som pekar på hälsoeffekter av olika kryddor och örter är att det sällan är jämförbart med vad vi köper på ICA och låter stå i kryddhyllan lång tid.

Mycket bygger ju på färska kryddor och ärter, inte finmalt, strålbehandlat, transporterat och förvarat under lång tid. Hur gärna man än vill hoppas på det så behöver inte Santa Marias madrascurry ge den eventuella effekten som den färska i Indien.

[WHITEFOLKS]

Man ska kunna förbättra upptaget av det intressanta i gurkmeja med piperine. Så man får gärna kombinera gurkmeja och svartpeppar, iaf teoretiskt.