L-karnitin skyddar mot skadeverkningar av aspartam

[King Grub]

Aspartame (ASP) has been used as an alternative to sucrose for diabetics and obese people worldwide. Co-administration of L-carnitine (LC) with ASP has a protective effect against the liver and kidney toxicity induced of ASP. The goal of the investigation was to assess the enhancement of LC effect on the cardiac toxicity caused of ASP. The rats were divided into 6 groups: control with saline, LC (10 mg/kg), ASP (75 mg/kg), ASP (150 mg/kg), LC with 75 mg/kg of ASP, and LC with 150 mg/kg ASP. The antioxidants were determined by measuring the activities of myeloperoxidase, xanthine oxidase, superoxide dismutase, catalase, and glutathione peroxidase, and by assessing the levels of lipid peroxidation, total thiols, and glutathione. There was a significant elevation in LPO, in conjunction with a significant decline in the enzymatic antioxidants superoxide dismutase, catalase, and glutathione peroxidase and the non-enzymatic antioxidants glutathione and thiols. The cardiac myofibrils were found in a disarrayed pattern in ASP treated-animals as compared to the control rats. The animals treated with ASP-HD showed more than one apoptotic cell with a large tail and a small head, and the relaxed loops of the damaged DNA were extended to form a comet-shaped structure. These effects may be due to the excessive generation of reactive oxygen species by ASP, which reduces cardiac function. Co-administration of LC with ASP improved all of the above-mentioned parameters that were disrupted of ASP alone. This study evidences a sufficient originality in showing how LC plays a positive role against cardiac toxicity of ASP.

PLoS One. 2018 Nov 7;13(11):e0204913. Role of L-carnitine in protection against the cardiac oxidative stress induced by aspartame in Wistar albino rats.

[svartakronan]

Vilka livsmedel hittar man L karnitin i?

Skickat från min G3311 via Tapatalk

[Sverker]

Har aldrig sett någon sammanställning.
Jag antar att något med hög fettbränning och mycket mitokondrier är rika på karnitin. Satsa på rött kött eller lever.

Misstänker också att upptaget av karnitin är dåligt och därför måste man ta 10 mg / kg kroppsvikt för att få effekt.

[kvarnis]

Karnitin har väl en inhiberande effekt på sköldkörteln så kanske inget man ska ta dagligen.

[Ola Wallengren]

Så vitt jag vet är det inte fastslaget att dessa "toxiska" effekter av aspartam finns eller är relevanta för människor. Så varför bry sig om karnitin (eller denna studien) i så fall?

[Sverker]

These effects may be due to the excessive generation of reactive oxygen species by ASP, which reduces cardiac function.

Jag antog att det var metanolen och bildandet av formaldehyd var den giftiga effekten av aspartam. Att formaldehyden reagerade med viktiga protein i cellerna.

Men det är kanske viktigt att fylla på med antioxidanter istället


...ifall man nu är tveksam till aspartam.