Inget stöd för att omega-3-tillskott skyddar mot någon form av hjärt- och kärlsjukdom

[King Grub]

Key Points

Question Does supplementation with marine-derived omega-3 fatty acids have any associations with reductions in fatal or nonfatal coronary heart disease in people at high risk of cardiovascular disease?

Findings

This meta-analysis of 10 trials involving 77 917 participants demonstrated that supplementation with marine-derived omega-3 fatty acids for a mean of 4.4 years had no significant association with reductions in fatal or nonfatal coronary heart disease or any major vascular events.

Meaning

The results provide no support for current recommendations to use omega-3 fatty acid supplements for the prevention of fatal coronary heart disease or any cardiovascular disease in people who have or at high risk of developing cardiovascular disease.

Importance

Current guidelines advocate the use of marine-derived omega-3 fatty acids supplements for the prevention of coronary heart disease and major vascular events in people with prior coronary heart disease, but large trials of omega-3 fatty acids have produced conflicting results.

Objective

To conduct a meta-analysis of all large trials assessing the associations of omega-3 fatty acid supplements with the risk of fatal and nonfatal coronary heart disease and major vascular events in the full study population and prespecified subgroups.

Data Sources and Study Selection

This meta-analysis included randomized trials that involved at least 500 participants and a treatment duration of at least 1 year and that assessed associations of omega-3 fatty acids with the risk of vascular events.

Data Extraction and Synthesis

Aggregated study-level data were obtained from 10 large randomized clinical trials. Rate ratios for each trial were synthesized using observed minus expected statistics and variances. Summary rate ratios were estimated by a fixed-effects meta-analysis using 95% confidence intervals for major diseases and 99% confidence intervals for all subgroups.

Main Outcomes and Measures

The main outcomes included fatal coronary heart disease, nonfatal myocardial infarction, stroke, major vascular events, and all-cause mortality, as well as major vascular events in study population subgroups.

Results

Of the 77 917 high-risk individuals participating in the 10 trials, 47 803 (61.4%) were men, and the mean age at entry was 64.0 years; the trials lasted a mean of 4.4 years. The associations of treatment with outcomes were assessed on 6273 coronary heart disease events (2695 coronary heart disease deaths and 2276 nonfatal myocardial infarctions) and 12 001 major vascular events. Randomization to omega-3 fatty acid supplementation (eicosapentaenoic acid dose range, 226-1800 mg/d) had no significant associations with coronary heart disease death (rate ratio [RR], 0.93; 99% CI, 0.83-1.03; P = .05), nonfatal myocardial infarction (RR, 0.97; 99% CI, 0.87-1.08; P = .43) or any coronary heart disease events (RR, 0.96; 95% CI, 0.90-1.01; P = .12). Neither did randomization to omega-3 fatty acid supplementation have any significant associations with major vascular events (RR, 0.97; 95% CI, 0.93-1.01; P = .10), overall or in any subgroups, including subgroups composed of persons with prior coronary heart disease, diabetes, lipid levels greater than a given cutoff level, or statin use.

Conclusions and Relevance

This meta-analysis demonstrated that omega-3 fatty acids had no significant association with fatal or nonfatal coronary heart disease or any major vascular events. It provides no support for current recommendations for the use of such supplements in people with a history of coronary heart disease.

Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks. Jama, 31 January 2018.

https://jamanetwork.com/journals/jam...rticle/2670752

[ozzian]

Så man slipper trycka i sig dessa äckliga geléklumpar nu då?

[Max]

Ursprungligen postat av ozzian

Så man slipper trycka i sig dessa äckliga geléklumpar nu då?

Äter du omega-3 tillskott för att undvika hjärta-kärlsjukdom?

[Sverker]

Startålder på 64 år låter sent.

Kanske är det för sent att förebygga problem med blodkärlen då. Att inflammationerna och inlagringen av kalk redan tagit fart.

Väntar spänt på mer studier.

[ventilation]

Ursprungligen postat av Max

Äter du omega-3 tillskott för att undvika hjärta-kärlsjukdom?

I vilket syfte skulle man annars äta det?

[Max]

Ursprungligen postat av ventilation

I vilket syfte skulle man annars äta det?

Det finns många olika anledningar förespråkare brukar nämna, det var därför jag frågade. Personer som skriver på Kolozzeum brukar vara mer intresserade av ökad prestation misstänker jag.
Jag äter själv inte omega-3 som tillskott.

[exevision]

Ursprungligen postat av ventilation

I vilket syfte skulle man annars äta det?

Detta kanske?
http://www.kolozzeum.com/forum/showthread.php?t=230910

[Baskagge]

Eller så vill man bara ha lite större hjärna.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917688/

[leee]

Kan väl ta olivolja istället.

[Lillleif]

It provides no support for current recommendations for the use of such supplements in people with a history of coronary heart disease.

Som Sverker nämnde, medelåldern i studien var 64 år. De drar slutsatsen att om du redan har hjärtproblem skyddar inte intag av 1g omega 3 per dag mot ytterligare hjärtproblem.