Mättat fett och risk för stroke

[King Grub]

Background and aims

Because of the conflicting research results, the association between saturated fatty acid (SFA) consumption and the risk of stroke remains controversial. We conducted a meta-analysis to evaluate potential dose–response relation between SFA intake and stroke.

Methods and results

PubMed, Embase, the Cochrane Library Central Register of Controlled Trials, and Web of Science were searched. Summary relative risks (RRs) of the highest vs. the lowest category of SFA intake and their 95% confidence intervals (CIs) were pooled by random-effects models. Linear or nonlinear dose–response trend estimations were evaluated with data from categories of SFA consumption in each study. Fourteen studies involving a total of 598,435 participants were eligible for high vs. low meta-analysis, and 12 studies involving a total of 462,268 participants were eligible for the dose–response relation assessment. Higher dietary SFA intake was associated with a decreased overall risk for stroke (RR, 0.87; 95% CI, 0.78–0.96; I2 = 37.8%). A linear relation between SFA and stroke was explored (P = 0.01), the pooled RR of stroke per 10 g/day increase in SFA intake was 0.94 (95% CI, 0.89–0.98; P = 0.01).

Conclusion

This meta-analysis further demonstrated that a higher consumption of dietary SFA is associated with a lower risk of stroke, and every 10 g/day increase in SFA intake is associated with a 6% relative risk reduction in the rate of stroke. Further research is needed to explore the influence of specific SFA types and different macronutrient replacement models of SFA on the stroke risk.

Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 2, 10 February 2020, Pages 179-189. Dietary saturated fat intake and risk of stroke: Systematic review and dose–response meta-analysis of prospective cohort studies.

[Mäktigman]

Huh, mättat fett minskar risken för stroke? Det här var nytt för mig. Vad kan det bero på?

[Sagacity]

Ursprungligen postat av Mäktigman

Huh, mättat fett minskar risken för stroke? Det här var nytt för mig. Vad kan det bero på?

En kardiolog jag är bekant med nämnde att på konferenser pratar man mycket mer om inflammation. Det har ju egentligen aldrig fnnits någon klar data att fett skulle vara skadligt. Tvärtom har vi ju ätit fett från djur så länge vi varit människor.