Kolozzeum Forum - Sveriges största träningsforum
Gammal 2020-07-08, 17:56   #1
King Grub
Chefsarkitekt Oljebyxor
 
King Grubs avatar
 
Reg.datum: Mar 2002
Ort: Norrtälje
Inlägg: 78 267
Sukralos och tarmcancer

Citat:
Sucralose is a calorie-free high-intensity artificial sweetener that is widely used in thousands of foods and beverages all over the world. Although it was initially regarded as a safe, inert food additive, its adverse effect on gut microbiota and health has drawn more and more attention as evidence accumulates. Studies by us and others revealed that sucralose exacerbated gut damage and inflammation in animal models for inflammatory bowel disease (IBD), including those for both ulcerative colitis, and Crohn's disease. Our study demonstrated that sucralose greatly aggravated dextran sulfate sodium (DSS)-induced colitis along with causing changes in gut microbiota, the gut barrier and impaired inactivation of digestive proteases mediated by deconjugated bilirubin. It is well-documented that IBD greatly increases the risk of colorectal cancer (CRC), the globally third-most-common cancer, which, like IBD, has a high rate in the developed countries. Azoxymethane (AOM)/DSS has been the most commonly used animal model for CRC. In this study, we further explored the effect of sucralose on tumorigenesis and the possible mechanism involved using the AOM/DSS mouse model. First, 1.5 mg/ml sucralose was included in the drinking water for 6 weeks to reach a relatively stable phase of impact on gut microbiota. Then, 10 mg/kg AOM was administered through intraperitoneal injection. Seven days later, 2.5% DSS was put in the drinking water for 5 days, followed by 2 weeks without DSS. The 5 days of DSS was then repeated, and the mice were sacrificed 6 weeks after AOM injection. The results showed that sucralose caused significant increases in the number and size of AOM/DSS-induced colorectal tumors along with changes in other parameters such as body and spleen weight, pathological scores, mortality, fecal β-glucuronidase and digestive proteases, gut barrier molecules, gut microbiota, inflammatory cytokines and pathways (TNFα, IL-1β, IL-6, IL-10, and TLR4/Myd88/NF-κB signaling), and STAT3/VEGF tumor-associated signaling pathway molecules. These results suggest that sucralose may increase tumorigenesis along with dysbiosis of gut microbiota, impaired inactivation of digestive protease, damage to the gut barrier, and exacerbated inflammation.
Front Oncol.. 2020 Jun 3;10:710. Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota.

https://www.frontiersin.org/articles...020.00710/full
__________________


Angående PM-rådgivning!
King Grub är inte uppkopplad   Svara med citat
Gammal 2020-07-08, 17:59   #2
King Grub
Chefsarkitekt Oljebyxor
 
King Grubs avatar
 
Reg.datum: Mar 2002
Ort: Norrtälje
Inlägg: 78 267
Cytotoxicitet och genotoxicitet.

Citat:
One of the most used sweeteners in the world is Sucralose. With sweetening power 600 times greater than sucrose, its use grows among those who seek to cut calories. Research shows that when heated, Sucralose generates toxic products that attack the organism and interact with DNA. Our objective was to test this sweetener under unheated conditions and at average concentrations of consumption, evaluating parameters of cytotoxicity, genotoxicity, and immunotoxicity. For this purpose, we made use of lymphocyte cultures and the analysis of their CD3+ , CD4+ ,and CD8+ subpopulations. In a complementary way, the mechanism of action is proposed here by computational methods. Our results showed that Sucralose reduces non-selectively the total lymphocytes due to falls in the levels of the CD4+ , CD8+ , and CD4+ CD8+ subpopulation. We observed an increase in the level of DNA damage and a gradual incidence of structural changes in the lymphocyte chromosomal sets. It was possible to propose that Sucralose modulate the gene expression, interfering, especially the MAPK8, APTX, and EID1 genes. This article presents the results of an evidence-based approach to the safety of human health in the use of Sucralose.Finally, this study points out that Sucralose has cytotoxic, genotoxic, and mutagenic effects in the concentrations and conditions tested in human lymphocyte cell culture.
Clin Exp Pharmacol Physiol. 2020 Jun 16. Sucralose Causes Non-Selective CD4 and CD8 Lymphotoxicity via Probable Regulation of the MAPK8 / APTX / EID1 Genes: An in vitro/in Silico Study.
__________________


Angående PM-rådgivning!
King Grub är inte uppkopplad   Svara med citat
Gammal 2020-07-08, 21:11   #3
Ett Orm
Silver lifter
 
Ett Orms avatar
 
Reg.datum: Jun 2011
Ort: Mitt i Sverige, lite åt sidan..
Inlägg: 2 611
Citat:
along with dysbiosis of gut microbiota,
När man skriver dysbiosis menar man förändring eller försämring av tarmbiotan?
__________________
ᕦ( ˘ᴗ˘ )ᕤ
Ett Orm är inte uppkopplad   Svara med citat
Gammal 2020-07-08, 21:22   #4
King Grub
Chefsarkitekt Oljebyxor
 
King Grubs avatar
 
Reg.datum: Mar 2002
Ort: Norrtälje
Inlägg: 78 267
Försämrad eller förstörd.
__________________


Angående PM-rådgivning!
King Grub är inte uppkopplad   Svara med citat
Gammal 2020-07-08, 22:57   #5
Ett Orm
Silver lifter
 
Ett Orms avatar
 
Reg.datum: Jun 2011
Ort: Mitt i Sverige, lite åt sidan..
Inlägg: 2 611
Citat:
Ursprungligen postat av King Grub Visa inlägg
Försämrad eller förstörd.
Thx.

Vet man ens tillräckligt om tarmbakterier för att kunna säga att den blir försämrad, om nästan allt dör så visst, men om bara vissa minskar kan man då säga att den försämras när den kanske bara förändras eller anpassas?
Eller man kanske börjar få lite koll på läget vilka de stora spelarna är i bacilluskvärden?
__________________
ᕦ( ˘ᴗ˘ )ᕤ
Ett Orm är inte uppkopplad   Svara med citat


Svara

Ämnesverktyg
Visningsalternativ

Regler för att posta
Du får inte posta nya ämnen
Du får inte posta svar
Du får inte posta bifogade filer
Du får inte redigera dina inlägg

BB-kod är
Smilies är
[IMG]-kod är
HTML-kod är av

Forumhopp


Alla tider är GMT +1. Klockan är nu 09:29.


Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Svensk översättning av: Anders Pettersson
Copyright 2015, Kolozzeum (TM)