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Gammal 2018-08-28, 23:39   #16
tramadol
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Reg.datum: Aug 2018
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Köpte hmi för runt 500kr. Ingen aning om det hjälpte ett skit, tror inte det. Men gillar att testa nya kosttillskott så ingen fara skedd^^
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Gammal 2018-10-03, 10:48   #17
King Grub
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Ort: Norrtälje
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Citat:
Age-related sarcopenia and dynapenia are associated with frailty and metabolic diseases. Resistance exercise training (RET) adjuvant to evidence-based nutritional intervention(s) have been shown as mitigating strategies. Given that HMB supplementation during RET improves lean body mass in younger humans (Wilson et al., 2014), and that we have shown that HMB acutely stimulates muscle protein synthesis (MPS) and inhibits breakdown; we hypothesized that chronic supplementation of HMB adjuvant to RET would enhance MPS and muscle mass/function in older people.We recruited 16 healthy older men (PLA: 68.5±1.0y, HMB: 67.8±1.1y) for a randomised double-blind-placebo (PLA) controlled trial (HMB 3 x 1g/day vs. PLA) involving a 6-week unilateral progressive RET regime (6 x 8 repetitions, 75% 1-RM, 3.wk-1). D2O dosing was performed over the first two weeks (0-2w) and last two weeks (4-6w) with bilateral vastus lateralis (VL) biopsies at 0-2 and 4-6 weeks (each time 75±2 min after a single bout of RE) for quantification of early and later MPS responses and post-RE myogenic gene expression. Thigh lean mass was measured by DXA, VL thickness and architecture (fibre length and pennation angle) by ultrasound at 0/3/6 weeks, and strength by knee extensor 1-RM testing and MVC by isokinetic dynamometry (approx. every 10 days). RET induced strength increases (1-RM) in the exercised leg in both groups (398±22N to 499±30N HMB vs. 396±29N to 510±43N PLA (both P<0.05)). In addition, MVC also increased (179±12Nm to 203±12Nm HMB vs. 185±10Nm to 217±11Nm PLA (both P<0.05); there were no group differences. Muscle thickness of the VL increased significantly in the exercised leg in both groups, with no group differences. Thigh lean mass (by DXA) rose to significance only in the HMB group (by 5.8% to 5734±245g p=0.015 vs. 3.0% to 5644±323g P=0.06 in PLA). Interestingly, while MPS remained unchanged in the UT legs of both groups between 0-2 weeks e.g. ∼1.10 ±0.07%.d-1 (HMB) and 1.12±0.07%.d-1(PLA), the trained leg (T) exhibited increased MPS in the HMB group only at 0-2-weeks (1.42±0.10%.d-1, P<0.05) compared with untrained leg (UT): but was not different at 4-6-weeks: 1.27±0.05%.d-1. However, there were no significant differences in MPS between the HMB and PLA groups at any given time point.

We also observed significant inductions of c-Myc gene expression following each acute RE bout, with no group differences, with no changes in other muscle atrophy/hypertrophy or myogenic transcription factor genes we measured. RET with adjuvant HMB supplements in free-living healthy older men did not enhance muscle strength or mass significantly, over that of RET alone (PLA), despite enhancing MPS over the first two weeks. Longer and larger studies are needed to determine the potential effects of HMB supplementation; translating to any functional benefit.
A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults. Clinical Nutrition, 27 September 2018.
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