Negativa effekter av sittande mildras inte av att röra på sig - Kolozzeum Forum

King Grub · 2017-11-13, 12:46

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Prolonged sitting induces endothelial dysfunction in healthy young adults which has been demonstrated to be offset by intermittent fidgeting and standing. No information exists on the impact of sitting and endothelial dysfunction in sedentary middle-aged adults, and whether common workplace counter-interventions (i.e. desk-standing/desk-pedaling) mitigate sitting-induced endothelial dysfunction.

PURPOSE:

The objective of this study was to examine whether breaking up prolonged sitting with intermittent standing or under-desk pedaling prevents sitting-induced popliteal artery endothelial dysfunction in middle-aged sedentary, overweight/obese office workers.

HYPOTHESIS:

We tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by intermittent standing or desk pedaling.

METHODS:

Thirteen middle-aged, sedentary overweight/obese subjects (10 males, 3 females; age: 38±3 yrs; BMI: 29.7±2 kg/m) participated in three separate testing sessions in a randomized order: 1) four hours of uninterrupted sitting; 2) four hours of sitting interrupted with four 10-minute bouts of standing; and 3) four hours of sitting interrupted with four 10-minute bouts of light-intensity desk pedaling. Doppler ultrasound measured popliteal artery flow mediated dilation (FMD), and associated measures (e.g. shear rate, blood velocity) were measured immediately prior to and immediately following each intervention (sit, stand, and desk pedaling).

RESULTS:

Four hours of uninterrupted sitting induced a significant impairment in popliteal artery FMD (baseline: 3.1±0.3%, post: 1.6±0.5%, P<0.05). Interestingly, neither intermittent standing (baseline: 3.2±0.4%, post: 1.9±0.5%, P<0.05) nor intermittent desk pedaling (baseline: 3.2±0.4%, post: 1.9±0.4%, P<0.05) was effective at preventing excessive sitting-induced endothelial dysfunction.

CONCLUSION:

Prolonged sitting-induced leg endothelial dysfunction cannot be prevented by brief intermittent bouts of standing or desk pedaling in middle-aged sedentary overweight/obese adults.

Workplace Strategies to Prevent Sitting-induced Endothelial Dysfunction. Medicine and Science in Sports and Exercise, 7 November 2017.

Bob90 · 2017-11-13, 13:44

Damned if you do, damned if you don't

Vi ska alla dö någon gång :p

meow · 2017-11-13, 23:54

Var det inte någon studie som sa att träning x tidsenheter motverkade sittande i y tidsenheter?
Har för mig att du la upp en för någon månad sen :p

Konradsson · 2017-11-13, 23:58

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Ursprungligen postat av meow

Var det inte någon studie som sa att träning x tidsenheter motverkade sittande i y tidsenheter?
Har för mig att du la upp en för någon månad sen :p

Det finns tidigare studier som visar samma sak - att träning inte kompenserar för stillasittande. Exempelvis denna: http://www.kolozzeum.com/forum/showthread.php?t=196239

meow · 2017-11-14, 00:22

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Ursprungligen postat av Konradsson

Det finns tidigare studier som visar samma sak - att träning inte kompenserar för stillasittande. Exempelvis denna: http://www.kolozzeum.com/forum/showthread.php?t=196239

Ja det vet jag
Men är rätt säker på att det fanns en rapport som faktiskt sa motsatsen

Bärsärk · 2017-11-14, 06:46

4 timmar oavbrutet sittande är ju väldigt mycket, hur kan man ens sitta ner så länge utan att behöva gå på toa?

Agitator · 2017-11-14, 07:01

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Ursprungligen postat av Bärsärk

4 timmar oavbrutet sittande är ju väldigt mycket, hur kan man ens sitta ner så länge utan att behöva gå på toa?

Inga problem alls!

Termy · 2017-11-14, 07:51

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Ursprungligen postat av meow

Ja det vet jag
Men är rätt säker på att det fanns en rapport som faktiskt sa motsatsen

Menar du denna?
Med Sci Sports Exerc. 2015 Apr;47(4):843-9. doi: 10.1249/MSS.0000000000000479. Effect of prolonged sitting and breaks in sitting time on endothelial function. Thosar SS1, Bielko SL, Mather KJ, Johnston JD, Wallace JP.

Abstract
Sitting time (ST) is associated with cardiovascular disease risk factors, whereas breaking ST has been reported to be beneficial for reducing cardiovascular risk.

PURPOSE:
The objective of this study is to examine the effects of breaking ST on superficial femoral artery (SFA) endothelial function.

HYPOTHESES:
1) Prolonged sitting would induce endothelial dysfunction and changes in shear forces, and 2) breaking ST with brief periods of activity would prevent attenuation in endothelial function.

METHODS:
Twelve nonobese men (24.2 ± 4.2 yr) participated in two randomized 3-h sitting trials. In the sitting (SIT) trial, subjects were seated on a firmly cushioned chair for 3 h without moving their lower extremities. In the breaking ST trial (ACT), subjects sat similar to the SIT trial but walked on a treadmill for 5 min at 2 mph at 30 min, 1 h 30 min, and 2 h 30 min during the sitting interval. SFA flow-mediated dilation (FMD) was assessed at baseline, 1 h, 2 h, and 3 h in each trial. Statistical analyses were performed using dependent variables SFA FMD and shear rates. Significance was set at P ≤ 0.05

RESULTS:
In the SIT trial, there was a significant decline in SFA FMD from baseline to 3 h (baseline, 4.72% ± 3.78%; 1 h, 0.52% ± 0.85%; 2 h, 1.66% ± 1.11%; 3 h, 2.2% ± 2.15; P < 0.05 by ANOVA) accompanied by a decline in mean shear rate and antegrade shear rate but no difference in shear rate (area under the curve). By two-way repeated-measures ANOVA, ACT prevented the sitting-induced decline in FMD (baseline, 4.5% ± 2.3%; 1 h, 5.04% ± 2.85%; 2 h, 5.28% ± 5.05%; 3 h, 6.9% ± 4.5%) along with no decline in shear rates.

CONCLUSION:
Three hours of sitting resulted in a significant impairment in shear rate and SFA FMD. When light activity breaks were introduced hourly during sitting, the decline in FMD was prevented.