För den intresserade.
Visar också hur lite man vet. Särskilt om muskelnedbrytning. Man vet i princip ingenting om hur den fungerar och vilken inverkan den har på något. Går fortfarande inte att mäta ordentligt.
Citat:
The nutritional regulation of protein and amino acid balance in human skeletal muscle carried out by the authors with Mike Rennie is reviewed in the context of a simple physiological model for the regulation of the maintenance and growth of skeletal muscle, the “Bag Theory.” Beginning in London in the late 1970s the work has involved the use of stable isotopes to probe muscle protein synthesis and breakdown with two basic experimental models, primed‐dose continuous tracer infusions combined with muscle biopsies and arterio‐venous (A‐V) studies across a limb, most often the leg, allowing both protein synthesis and breakdown as well as net balance to be measured. In this way, over a 30y period, the way in which amino acids and insulin mediated the anabolic effect of a meal has been elaborated in great detail confirming the original concepts of bag filling within the muscle endomysial “bag,” which is limited by the “bag” size, unless bag enlargement occurs, which requires new collagen synthesis. Finally we briefly review some new developments involving 2H2O labelling of muscle proteins.
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The application of stable‐isotope tracers to study human musculoskeletal protein turnover: a tale of bag filling and bag enlargement. J Physiol, 11 August 2018.
http://docdro.id/UOamPOh