[Eddie Vedder]

Ursprungligen postat av stålballe

Hur påverkar intag av EAA nivåerna/insöndring av IGF1?

Letade lite hastigt, fann inget med vältränade individer specifikt men däremot finns gott om studier.

Otränade män:

Summary. This study examined 10 wks of resistance training and the ingestion of supplemental protein and amino acids on muscle performance and markers of muscle anabolism. Nineteen untrained males were randomly assigned to supplement groups containing either 20 g protein (14 g whey and casein protein, 6 g free amino acids) or 20 g dextrose placebo ingested 1 h before and after exercise for a total of 40 g/d. Participants exercised 4 times/wk using 3 sets of 6–8 repetitions at 85–90% of the one repetition maximum. Data were analyzed with two-way ANOVA (p < 0.05). The protein supplement resulted in greater increases in total body mass, fat-free mass, thigh mass, muscle strength, serum IGF-1, IGF-1 mRNA, MHC I and IIa expression, and myofibrillar protein. Ten-wks of resistance training with 20 g protein and amino acids ingested 1 h before and after exercise is more effective than carbohydrate placebo in up-regulating markers of muscle protein synthesis and anabolism along with subsequent improvements in muscle performance.

http://www.springerlink.com/content/d7681t67505751r0/

Effects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strength. Amino Acids. 2007;32(4):467-77.

Äldre individer:

Decreases in whole-body lean mass can cause sarcopenia, a disease frequently found in the elderly. This condition is frequently associated with frailty and disability in aging as well as the onset and progression of several geriatric syndromes. Sarcopenia therefore must be managed with multidimensional approaches that include physical training, nutritional support, and metabolic and anabolic treatment. The purpose of our study was to assess the effect of an orally administered special mixture of amino acids (AAs) in elderly subjects with reduced lean body mass and sarcopenia. A randomized, open-label, crossover study was conducted in 41 elderly subjects (age range: 66–84 years) with sarcopenia, assigned to 2 distinct treatments (AAs and placebo). All subjects had normal body weight (body mass index within 19–23). The AA treatment consisted of 70.6 kcal/day (1 kcal = 4.2 kJ) of 8 g of essential AA snacks, given at 10:00 am and 5:00 pm. Lean mass was measured with dual-energy x-ray absorptiometry in leg, arm, and trunk tissues. Significant increases in whole-body lean mass in all areas were seen after 6 months and more consistently after 18 months of oral nutritional supplementation with AAs. Fasting blood glucose, serum insulin, and homeostatic model assessment of insulin resistance (an index of insulin resistance) significantly decreased during AA treatment. Furthermore, a significant reduction in serum tumor necrosis factor–α (TNF-α) and a significant increase in both insulin-like growth factor–1 (IGF-1) serum concentrations and in the IGF-1/TNF-α ratio were also found. No significant adverse effects were observed during AA treatment. These preliminary data indicate that nutritional supplements with the oral AA mixture significantly increased whole-body lean mass in elderly subjects with sarcopenia. The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability.

http://www.ajconline.org/article/PII...03998/fulltext

Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol. 2008 Jun 2;101(11A):69E-77E.

Äldre kvinnor:

Results: Ingestion of 7.5g EAA acutely stimulated FSR in both groups at 0 months (P<0.05). Basal FSR at three months was increased in SUP only. The magnitude of the acute response to EAA was unaltered after 3 months in SUP. LBM increased in SUP only (P<0.05). 1RM strength remained unchanged in both groups. Basal IGF-1 protein expression increased in SUP after 3 months (P=0.05), with no changes in AR or total and phosphorylated Akt, mTOR, S6K1 and 4E-BP1.

Conclusion: EAA improved lean body mass and basal muscle protein synthesis in older individuals. The acute anabolic response to EAA supplementation is maintained over time and can improve lean body mass, possibly offsetting the debilitating effects of sarcopenia.

http://jcem.endojournals.org/cgi/rap...jc.2008-1564v1

Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and IGF-1 Expression in Older Women. J Clin Endocrin Metab. doi:10.1210/jc.2008-1564