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Gammal 2005-12-18, 11:54   #1
King Grub
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Reg.datum: Mar 2002
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Aspartams neurotoxicitet

Det är inte så enkelt som att testa en substans, t ex aspartam för sig, och undersöka dess toxicitet under kontrollerade förhållanden. Här visas, hur aspartam blir neurotoxiskt tillsammans med E104, kinolingult, ett syntetiskt färgämne, som är godkänt för använding till alla livsmedel som får färgas och till marmelad och sylt. Det som inte påverkar ensamt blir otrevligt tillsammans med andra substanser, och det här var bara en substans.

"Although the use of single food additives at their regulated concentrations is believed to be relatively safe in terms of neuronal development, their combined effects remain unclear.

We therefore examined the neurotoxic effects of four common food additives in combinations of two (Brilliant Blue and L-glutamic acid, Quinoline Yellow and aspartame) to assess potential interactions.

Two independent models were used to analyse combination effects: effect additivity and dose additivity.

Significant synergy was observed between combinations of Brilliant Blue with L-glutamic acid, and Quinoline Yellow with aspartame, in both models.

Theoretical exposure to additives was calculated based on analysis of content in foodstuff, and estimated percentage absorption from the gut. Inhibition of neurite outgrowth was found at concentrations of additives theoretically achievable in plasma by ingestion of a typical snack and drink."

Toxicol Sci. 2005 Dec 13; Synergistic Interactions Between Commonly Used Food Additives in a Developmental Neurotoxicity Test.

http://toxsci.oxfordjournals.org/cgi/reprint/kfj073v1
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