[PureWhey]

https://link.springer.com/article/10...04-019-02490-x

Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies in humans are very rarely accessible. Thus, our project aimed at investigating the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. Analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. To ensure the specificity of the effects measured, a comprehensive screening for prohibited performance-enhancing substances was also carried out. Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations prior to administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. The same hypertrophic effects were also detected in vitro in C2C12 myotubes. Even more relevant with respect to sports performance, significantly more pronounced increases in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectivity of an ecdysterone supplementation with respect to sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2 “other anabolic agents”.

Conclusion

This project demonstrates the performance-enhancing efect
of ecdysterone in humans. Thus, our results strongly suggest
including ecdysterone in class S1 “Anabolic Agents”. As it is
reported in the literature, the mechanism of action of ecdysterone appears as independent from the androgen receptor
activation, but it is rather exhibited by the activation of the
estrogen receptor beta. However, further investigations on
the activity of ecdysterone are recommended. They should
also include a controlled administration trial of ecdysterone
in humans to elucidate the metabolism of ecdysterone and
to evaluate possibilities for its improved detection in doping
control analyses.

A group of men who exercised the recommended dose of 2 capsules of Peak Ecdysone per day [Ec1], which amounts to 12 milligrams of ecdysterone per day. The men who did not train also took this dose. Another group of physically active men took 8 capsules of Peak Ecdysone [Ec2] daily. That amounts to 48 milligrams ecdysterone per day.

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The quantifcation of ecdysterone in the supplements revealed
an amount of 6 mg per capsule, which is considerably lower
than the amount labelled on the bottle (i.e. 100 mg per capsule). Thus, a daily dose of 12 mg of ecdysterone, i.e. 0.15 mg/
kg BW in an 80-kg volunteer, was administered in Ec1 and
CO, while the high-dose group (Ec2) received a daily dose of
48 mg of ecdysterone or 0.6 mg/kg BW in an 80-kg volunteer.