Nilsjohan
2007-07-22, 16:27
Ibland när det pratas om proteinrik kost så nämns Rabbit starvation syndrome. Men litteraturen kring detta syndrom verkar knapp. Har bara hittat några få artiklar där Rabbit starvation syndrome nämns.
Tidigare har jag sett Grub referera till den här studien: Int J Sport Nutr Exerc Metab. 2006 Apr;16(2):129-52. A review of issues of dietary protein intake in humans (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16779921&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum)
Jag tror att det var på Body som någon refererade till en artikel av Eaton (inget abstract tillgängligt): N Engl J Med. 1985 Jan 31;312(5):283-9. Paleolithic nutrition. A consideration of its nature and current implications. (http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2981409&dopt=Abstract)
Där jag hittat mest information: American Journal of Clinical Nutrition, Vol. 71, No. 3, 682-692, March 2000: Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets (http://www.ajcn.org/cgi/content/full/71/3/682)
Excess consumption of dietary protein from the lean meats of wild animals leads to a condition referred to by early American explorers as “rabbit starvation,” which initially results in nausea, then diarrhea, and then death. Clinical documentation of this syndrome is virtually nonexistent, except for a single case study. Despite the paucity of clinical data, it is quite likely that the symptoms of rabbit starvation result primarily from the finite ability of the liver to up-regulate enzymes necessary for urea synthesis in the face of increasing dietary protein intake. Rudman et al showed that the mean maximal rate of urea synthesis (MRUS) in normal subjects is 65 mg N ·h21 · kg body wt20.75 (range: 55–76 mg N·h21·kg body wt20.75) and that protein intakes that exceeded the MRUS resulted in hyperammonemia and hyperaminoacidemia. Using Rudman et al’s data (assuming 16% N/g protein), we calculated the mean maximal protein intake for an 80-kg subject to be 250 g/d (range: 212–292 g/d). For a 12 552-kJ energy intake, the mean maximal dietary protein intake would be 35.1% of energy (range: 29.7–40.9% of energy). Therefore, dietary protein intakes greater than values in this range may result in hyperammonemia and hyperaminoacidemia, which in turn likely cause some of the clinical symptoms responsible for the rabbit starvation syndrome described by explorers.
Den singel case study som nämns är: Lieb CW. The effects on human beings of a twelve months' exclusive meat diet. JAMA 1929;93:20–2.
Jag är inte orolig för att drabbas av detta själv, då jag ligger på ca 2gram protein per kg och dag, men det skulle vara intressant att veta lite mer om detta syndrom. Har någon mer information att förmedla angående högt intag av protein så får de gärna posta i tråden.
Tidigare har jag sett Grub referera till den här studien: Int J Sport Nutr Exerc Metab. 2006 Apr;16(2):129-52. A review of issues of dietary protein intake in humans (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16779921&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum)
Jag tror att det var på Body som någon refererade till en artikel av Eaton (inget abstract tillgängligt): N Engl J Med. 1985 Jan 31;312(5):283-9. Paleolithic nutrition. A consideration of its nature and current implications. (http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2981409&dopt=Abstract)
Där jag hittat mest information: American Journal of Clinical Nutrition, Vol. 71, No. 3, 682-692, March 2000: Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets (http://www.ajcn.org/cgi/content/full/71/3/682)
Excess consumption of dietary protein from the lean meats of wild animals leads to a condition referred to by early American explorers as “rabbit starvation,” which initially results in nausea, then diarrhea, and then death. Clinical documentation of this syndrome is virtually nonexistent, except for a single case study. Despite the paucity of clinical data, it is quite likely that the symptoms of rabbit starvation result primarily from the finite ability of the liver to up-regulate enzymes necessary for urea synthesis in the face of increasing dietary protein intake. Rudman et al showed that the mean maximal rate of urea synthesis (MRUS) in normal subjects is 65 mg N ·h21 · kg body wt20.75 (range: 55–76 mg N·h21·kg body wt20.75) and that protein intakes that exceeded the MRUS resulted in hyperammonemia and hyperaminoacidemia. Using Rudman et al’s data (assuming 16% N/g protein), we calculated the mean maximal protein intake for an 80-kg subject to be 250 g/d (range: 212–292 g/d). For a 12 552-kJ energy intake, the mean maximal dietary protein intake would be 35.1% of energy (range: 29.7–40.9% of energy). Therefore, dietary protein intakes greater than values in this range may result in hyperammonemia and hyperaminoacidemia, which in turn likely cause some of the clinical symptoms responsible for the rabbit starvation syndrome described by explorers.
Den singel case study som nämns är: Lieb CW. The effects on human beings of a twelve months' exclusive meat diet. JAMA 1929;93:20–2.
Jag är inte orolig för att drabbas av detta själv, då jag ligger på ca 2gram protein per kg och dag, men det skulle vara intressant att veta lite mer om detta syndrom. Har någon mer information att förmedla angående högt intag av protein så får de gärna posta i tråden.