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Visa fullständig version : Högt fruktos intag bör undvikas


Snakeyes
2005-03-11, 11:10
Det finns en rad produkter, främst MRP och gainers som innehåller fruktos, och där det påstås att detta är en relativt nyttig kolhydratkälla p g a av sitt låga GI värde. Det finns dock andra problem med fruktos. Bl a följande studier är värde att beakta:

Nutr Metab (Lond). 2005 Feb 21;2(1):5. Related Articles, Links


Fructose, insulin resistance, and metabolic dyslipidemia.

Basciano H, Federico L, Adeli K.

Clinical Biochemistry Division, Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. khosrow.adeli@sickkids.ca.

Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many parts of the world. The "obesity epidemic" appears to have emerged largely from changes in our diet and reduced physical activity. An important but not well-appreciated dietary change has been the substantial increase in the amount of dietary fructose consumption from high intake of sucrose and high fructose corn syrup, a common sweetener used in the food industry. A high flux of fructose to the liver, the main organ capable of metabolizing this simple carbohydrate, perturbs glucose metabolism and glucose uptake pathways, and leads to a significantly enhanced rate of de novo lipogenesis and triglyceride (TG) synthesis, driven by the high flux of glycerol and acyl portions of TG molecules from fructose catabolism. These metabolic disturbances appear to underlie the induction of insulin resistance commonly observed with high fructose feeding in both humans and animal models. Fructose-induced insulin resistant states are commonly characterized by a profound metabolic dyslipidemia, which appears to result from hepatic and intestinal overproduction of atherogenic lipoprotein particles. Thus, emerging evidence from recent epidemiological and biochemical studies clearly suggests that the high dietary intake of fructose has rapidly become an important causative factor in the development of the metabolic syndrome. There is an urgent need for increased public awareness of the risks associated with high fructose consumption and greater efforts should be made to curb the supplementation of packaged foods with high fructose additives. The present review will discuss the trends in fructose consumption, the metabolic consequences of increased fructose intake, and the molecular mechanisms leading to fructose-induced lipogenesis, insulin resistance and metabolic dyslipidemia.

PMID: 15723702 [PubMed - as supplied by publisher]

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J Clin Endocrinol Metab. 2004 Jun;89(6):2963-72. Related Articles, Links


Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.

Teff KL, Elliott SS, Tschop M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ.

Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA.

Previous studies indicate that leptin secretion is regulated by insulin-mediated glucose metabolism. Because fructose, unlike glucose, does not stimulate insulin secretion, we hypothesized that meals high in fructose would result in lower leptin concentrations than meals containing the same amount of glucose. Blood samples were collected every 30-60 min for 24 h from 12 normal-weight women on 2 randomized days during which the subjects consumed three meals containing 55, 30, and 15% of total kilocalories as carbohydrate, fat, and protein, respectively, with 30% of kilocalories as either a fructose-sweetened [high fructose (HFr)] or glucose-sweetened [high glucose (HGl)] beverage. Meals were isocaloric in the two treatments. Postprandial glycemic excursions were reduced by 66 +/- 12%, and insulin responses were 65 +/- 5% lower (both P < 0.001) during HFr consumption. The area under the curve for leptin during the first 12 h (-33 +/- 7%; P < 0.005), the entire 24 h (-21 +/- 8%; P < 0.02), and the diurnal amplitude (peak - nadir) (24 +/- 6%; P < 0.0025) were reduced on the HFr day compared with the HGl day. In addition, circulating levels of the orexigenic gastroenteric hormone, ghrelin, were suppressed by approximately 30% 1-2 h after ingestion of each HGl meal (P < 0.01), but postprandial suppression of ghrelin was significantly less pronounced after HFr meals (P < 0.05 vs. HGl). Consumption of HFr meals produced a rapid and prolonged elevation of plasma triglycerides compared with the HGl day (P < 0.005). Because insulin and leptin, and possibly ghrelin, function as key signals to the central nervous system in the long-term regulation of energy balance, decreases of circulating insulin and leptin and increased ghrelin concentrations, as demonstrated in this study, could lead to increased caloric intake and ultimately contribute to weight gain and obesity during chronic consumption of diets high in fructose.

Publication Types:
Clinical Trial

PMID: 15181085 [PubMed - indexed for MEDLINE]

Yankeee
2005-03-11, 11:26
:thumbup:

Tack för dem :)

King Grub
2005-03-11, 12:13
http://www.kolozzeum.com/kolozzeum/showthread.php?t=36810

Hoffa
2005-03-11, 12:27
Finns det något RDI för fruktos i relation till dessa studier?

Ett 200 grams päron/äpple till 3-4 måltider om dagen gör väl inte att man överstiger någon negativ fruktos mängd? Alltså 0.5 kg frukt om dagen i snitt.

aliquis
2005-03-11, 13:50
Ett 200 grams päron/äpple till 3-4 måltider om dagen gör väl inte att man överstiger någon negativ fruktos mängd? Alltså 0.5 kg frukt om dagen i snitt.
det är ju utspritt och frågan är ju vad alternativet är, skita i frukten? säkert mycket bättre... det är ju raffinerad fruktos som är onödig.

Snakeyes
2005-03-11, 17:52
det är ju utspritt och frågan är ju vad alternativet är, skita i frukten? säkert mycket bättre... det är ju raffinerad fruktos som är onödig.

Jag håller med, 2 - 4 olika frukter per dag är bara nyttigt.

aliquis
2005-03-11, 20:03
Jag håller med, 2 - 4 olika frukter per dag är bara nyttigt.
Rekommenderas ju 5 för vanliga människor, skadar nog inte med 7-8 för folk som är fysiskt aktiva heller... antioxidanterna lär ju ge en större positiv effekt än vad fruktsockret ger som är negativt.

King Grub
2005-03-11, 20:22
Rekommenderas ju 5 för vanliga människor.

Fem portioner frukt eller grönsaker är det väl, och att låta så många som möjligt av dom fem utgöras av grönsaker är nog inte fel. Om det är inte är gurka och salladsblad man väljer.