King Grub
2020-12-03, 12:38
Ingesting protein-containing supplements and foods provides essential amino acids (EAA) necessary to increase muscle and whole-body protein synthesis (WBPS). Large variations exist in the EAA composition of supplements and foods, ranging from free-form amino acids to whole protein foods. We sought to investigate how changes in peripheral EAA after ingesting various protein and free amino acid formats altered muscle and whole-body protein synthesis. Data were compiled from four previous studies that used primed, constant infusions of L-(ring-2H5)-phenylalanine and L-(3,3-2H2)-tyrosine to determine fractional synthetic rate of muscle protein (FSR), WBPS, and circulating EAA concentrations. Stepwise regression indicated that max EAA concentration (EAACmax; R2 = 0.524, p < 0.001), EAACmax (R2 = 0.341, p < 0.001), and change in EAA concentration (ΔEAA; R = 0.345, p < 0.001) were the strongest predictors for postprandial FSR, Δ (change from post absorptive to postprandial) FSR, and ΔWBPS, respectively. Within our dataset, the stepwise regression equation indicated that a 100% increase in peripheral EAA concentrations increases FSR by ~34%. Further, we observed significant (p < 0.05) positive (R = 0.420–0.724) correlations between the plasma EAA area under the curve above baseline, EAACmax, ΔEAA, and rate to EAACmax to postprandial FSR, ΔFSR, and ΔWBPS. Taken together our results indicate that across a large variety of EAA/protein-containing formats and food, large increases in peripheral EAA concentrations are required to drive a robust increase in muscle and whole-body protein synthesis.
Och som vanligt, BCAA konstaterat mer eller mindre värdelöst.
Numerous studies have demonstrated the inability of leucine and BCAAs alone to induce a rise in MPS or improvements in muscle hypertrophy or strength with chronic use [56,57,58,59,60]. Partial EAA administration (BCAA or leucine) produces a transient anabolic response, at best, due to the activation of translational molecular pathways [61]. Unless an adequate supply of EAA are available, MPB must increase to compensate for the lack of precursors. For this reason, the correlation of nearly all the EAA with FSR denotes the adequacy of precursor provision.
Nutrients 2020, 12(12), 3717. Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding.
https://www.mdpi.com/2072-6643/12/12/3717/htm
Och som vanligt, BCAA konstaterat mer eller mindre värdelöst.
Numerous studies have demonstrated the inability of leucine and BCAAs alone to induce a rise in MPS or improvements in muscle hypertrophy or strength with chronic use [56,57,58,59,60]. Partial EAA administration (BCAA or leucine) produces a transient anabolic response, at best, due to the activation of translational molecular pathways [61]. Unless an adequate supply of EAA are available, MPB must increase to compensate for the lack of precursors. For this reason, the correlation of nearly all the EAA with FSR denotes the adequacy of precursor provision.
Nutrients 2020, 12(12), 3717. Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding.
https://www.mdpi.com/2072-6643/12/12/3717/htm