King Grub
2017-07-30, 22:38
A new high-precision feeding system for lab mice reinforces the idea that the time of day food is eaten is more critical to weight loss than the amount of calories ingested.
Mice on a reduced calorie plan that ate only during their normal feeding/active cycle were the only ones among five groups to lose weight, despite consuming the same amount as another group fed during their rest time in daylight, according to the study at UT Southwestern Medical Center.
"Translated into human behavior, these studies suggest that dieting will only be effective if calories are consumed during the daytime when we are awake and active. They further suggest that eating at the wrong time at night will not lead to weight loss even when dieting," said Dr. Joseph S. Takahashi, Chairman of Neuroscience at UT Southwestern's Peter O'Donnell Jr. Brain Institute and Investigator with the Howard Hughes Medical Institute.
https://www.sciencedaily.com/releases/2017/07/170718091542.htm
Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.
Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. Cell Metabolism, Volume 26, Issue 1, p267–277.e2, 5 July 2017.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(17)30349-2
Mice on a reduced calorie plan that ate only during their normal feeding/active cycle were the only ones among five groups to lose weight, despite consuming the same amount as another group fed during their rest time in daylight, according to the study at UT Southwestern Medical Center.
"Translated into human behavior, these studies suggest that dieting will only be effective if calories are consumed during the daytime when we are awake and active. They further suggest that eating at the wrong time at night will not lead to weight loss even when dieting," said Dr. Joseph S. Takahashi, Chairman of Neuroscience at UT Southwestern's Peter O'Donnell Jr. Brain Institute and Investigator with the Howard Hughes Medical Institute.
https://www.sciencedaily.com/releases/2017/07/170718091542.htm
Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheel-running activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.
Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. Cell Metabolism, Volume 26, Issue 1, p267–277.e2, 5 July 2017.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(17)30349-2