Sneaky
2017-05-11, 08:56
The principal objective was to determine the extent to which physical activity (PA) accounts for differences in leukocyte telomere length (LTL) in a large random sample of U.S. adults. Another purpose was to assess the extent to which multiple demographic and lifestyle covariates affect the relationship between PA and LTL. A total of 5823 adults from the National Health and Nutrition Examination Survey (NHANES 1999–2002) were studied cross-sectionally. Employing the quantitative polymerase chain reaction method, LTL was compared to standard reference DNA. PA was indexed using MET-minutes using self-reported frequency, intensity, and duration of participation in 62 physical activities. Covariates were controlled statistically. Telomeres were 15.6 base pairs shorter for each year of chronological age (F = 723.2, P < 0.0001). PA was inversely related to LTL after adjusting for all the covariates (F = 8.3, P = 0.0004). Telomere base pair differences between adults with High activity and those in the Sedentary, Low, and Moderate groups were 140, 137, and 111, respectively. Adults with High activity were estimated to have a biologic aging advantage of 9 years (140 base pairs ÷ 15.6) over Sedentary adults. The difference in cell aging between those with High and Low activity was also significant, 8.8 years, as was the difference between those with High and Moderate PA (7.1 years). Overall, PA was significantly and meaningfully associated with telomere length in U.S. men and women. Evidently, adults who participate in high levels of PA tend to have longer telomeres, accounting for years of reduced cellular aging compared to their more sedentary counterparts
http://www.sciencedirect.com/science/article/pii/S0091743517301470
En annan studie från 2013 som också undersökte telomerens påverkan av träning :
After 29-year follow-up in 2003, mean LTL and the proportion of short (< 5 kB) telomeres were measured from DNA samples of a random subcohort of survivors (n = 204, mean age 76) using the Southern blot technique. Adjusted for age, body mass index (BMI), cholesterol and smoking in 1974, the moderate physical activity group had longer mean LTL (8.27 kB, SE 0.05) than the low (8.10 kB, SE 0.07), or high (8.10 kB, SE 0.05) physical activity groups (P = 0.03 between groups). Conversely, the proportion of short telomeres was lowest in the moderate physical activity group (11.35%, SE 0.25), and higher in the high (12.39%, SE 0.29), and the low physical activity (12.21%, SE 0.39) groups (P = 0.02 between groups). We conclude that the results of this observational cohort study give support to the idea that both low and high physical activity is in the long-term associated with factors shortening LTL.
http://www.sciencedirect.com/science/article/pii/S0531556512000344
http://www.sciencedirect.com/science/article/pii/S0091743517301470
En annan studie från 2013 som också undersökte telomerens påverkan av träning :
After 29-year follow-up in 2003, mean LTL and the proportion of short (< 5 kB) telomeres were measured from DNA samples of a random subcohort of survivors (n = 204, mean age 76) using the Southern blot technique. Adjusted for age, body mass index (BMI), cholesterol and smoking in 1974, the moderate physical activity group had longer mean LTL (8.27 kB, SE 0.05) than the low (8.10 kB, SE 0.07), or high (8.10 kB, SE 0.05) physical activity groups (P = 0.03 between groups). Conversely, the proportion of short telomeres was lowest in the moderate physical activity group (11.35%, SE 0.25), and higher in the high (12.39%, SE 0.29), and the low physical activity (12.21%, SE 0.39) groups (P = 0.02 between groups). We conclude that the results of this observational cohort study give support to the idea that both low and high physical activity is in the long-term associated with factors shortening LTL.
http://www.sciencedirect.com/science/article/pii/S0531556512000344