King Grub
2016-11-08, 08:41
Scope
Since the evidence on the role of diet on prostate cancer (PCa) prognosis is still controversial, we evaluated the long-term effects of fruit and vegetables consumption on survival after PCa.
Methods and results
A retrospective cohort study included 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy and followed-up to 2013. A validated food-frequency questionnaire assessed the usual diet in the two years before PCa diagnosis, including detailed fruit and vegetables consumption. Adjusted hazard ratio (HR) of death with 95% confidence interval (CI) were estimated using Fine-Gray models. PCa patients with a consumption of both fruit and vegetables above the median showed a higher 15-year overall survival probability than those with lower intakes (71% vs 58%, p = 0.04; HR = 0.66, 95% CI: 0.47-0.93). Consumption of foods rich in fiber (HR = 0.59, 95% CI: 0.41-0.86) and proanthocyanidins (HR = 0.58, 95% CI: 0.40-0.82) were inversely associated with overall mortality. Interestingly, proanthocyanidins (HR = 0.52; 95% CI: 0.27-0.98) and flavonols (HR = 0.40; 95% CI: 0.19-0.84) were inversely associated also with PCa-specific mortality.
Conclusion
High consumption of fruit and vegetables offers an advantage in survival among the rising number of men living after a PCa diagnosis, possibly through the epigenetic effect of some nutrients.
Fruit and vegetables consumption is directly associated to survival after prostate cancer. Molecular Nutrition and Food Research, 2 November 2016.
http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201600816/abstract?campaign=wolacceptedarticle
Since the evidence on the role of diet on prostate cancer (PCa) prognosis is still controversial, we evaluated the long-term effects of fruit and vegetables consumption on survival after PCa.
Methods and results
A retrospective cohort study included 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy and followed-up to 2013. A validated food-frequency questionnaire assessed the usual diet in the two years before PCa diagnosis, including detailed fruit and vegetables consumption. Adjusted hazard ratio (HR) of death with 95% confidence interval (CI) were estimated using Fine-Gray models. PCa patients with a consumption of both fruit and vegetables above the median showed a higher 15-year overall survival probability than those with lower intakes (71% vs 58%, p = 0.04; HR = 0.66, 95% CI: 0.47-0.93). Consumption of foods rich in fiber (HR = 0.59, 95% CI: 0.41-0.86) and proanthocyanidins (HR = 0.58, 95% CI: 0.40-0.82) were inversely associated with overall mortality. Interestingly, proanthocyanidins (HR = 0.52; 95% CI: 0.27-0.98) and flavonols (HR = 0.40; 95% CI: 0.19-0.84) were inversely associated also with PCa-specific mortality.
Conclusion
High consumption of fruit and vegetables offers an advantage in survival among the rising number of men living after a PCa diagnosis, possibly through the epigenetic effect of some nutrients.
Fruit and vegetables consumption is directly associated to survival after prostate cancer. Molecular Nutrition and Food Research, 2 November 2016.
http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201600816/abstract?campaign=wolacceptedarticle