mTOR och dess roll i cellulära signalmekanismer

[King Grub]

Many studies have been developed on the mammalian target of rapamycin: mTOR. mTOR is a threonine/kinase protein with major role in cellular growth signaling, regardless the tissue organism. In this study it was shown that mTOR is responsible for signaling both positively and negatively cell growth. In this review we see that the stimulus mTOR pathway allows health benefits, working in protein synthesis, cell growth, immunology, satiety and depression. Studies show that this threonine/kinase protein can be stimulated by various factors such as leucine, high-intensity exercise, omega 3, insulin and phosphatidic acid. Among the biochemical mediators involved in the activation of mTOR, Akt, p70 P13K and P6K1 are the most correlated. On the other hands, there are other studies showing detriments with stimulation of mTOR, as in some types of cancer, neurodegenerative diseases, aging muscle cells and fat tissue formation. However, as the theme covers various topics such as cell anabolism and immunology, it seems to be relevant continuity in research so that we can better understand the biochemical and physiological mechanisms of stimulation of mTOR. Thus, in a not so distant future, we may think of setting up specific cellular therapies, stimulating or inhibiting the mTOR pathway of the patient.

mTOR and its role in cell signaling. ICJR, 30 October 2016.

http://www.journalcra.com/sites/default/files/17427.pdf