King Grub
2016-09-20, 07:48
Background
Moderate consumption of red wine is associated with less cardiovascular events. We investigated whether red wine consumption counteracts the adverse vascular effects of cigarette smoking.
Methods
Participants smoked three cigarettes, alone or after drinking a titrated volume of red wine. Clinical chemistry, blood counts, plasma cytokine ELISAs, immuno-magnetic separation of CD14+ monocytes for gene expression analysis, fluorescence-activated cell sorting for microparticles, isolation of circulating mononuclear cells to measure telomerase activity were performed and urine cotinine levels were quantified.
Results
Compared to baseline, leukocytosis (p=0.019), neutrophilia (p<0.001), lymphopenia (p<0.001) and eosinopenia (p=0.008) were observed after only smoking. Endothelial as well as platelet-, monocyte- and leukocyte-derived microparticles (p<0.001 each) were elevated. In monocytes, mRNA expression of interleukin-6 (2.6±0.57-fold), tumor necrosis factor alpha (2.2±0.62-fold), and interleukin-1b (2.3±0.44-fold) were up-regulated as was interleukin-6 (1.2±0.12-fold) protein concentration in plasma. Smoking acutely inhibited mononuclear cell telomerase activity. Markers of endothelial damage, inflammation and cellular ageing were completely attenuated by red wine consumption.
Conclusion
Cigarette smoke results in acute endothelial damage, vascular as well as systemic inflammation and indicators of cellular ageing processes in otherwise healthy non-smokers. Pre-treatment with red wine was preventive. The findings underscore the magnitude of acute damage exerted by cigarette smoking in “occasional lifestyle smokers” and demonstrate the potential of red wine as a protective strategy to avert markers of vascular injury.
Red wine prevents the acute negative vascular effects of smoking. The American Journal of Medicine, 12 September 2016.
http://www.amjmed.com/article/S0002-9343(16)30912-3/pdf
Moderate consumption of red wine is associated with less cardiovascular events. We investigated whether red wine consumption counteracts the adverse vascular effects of cigarette smoking.
Methods
Participants smoked three cigarettes, alone or after drinking a titrated volume of red wine. Clinical chemistry, blood counts, plasma cytokine ELISAs, immuno-magnetic separation of CD14+ monocytes for gene expression analysis, fluorescence-activated cell sorting for microparticles, isolation of circulating mononuclear cells to measure telomerase activity were performed and urine cotinine levels were quantified.
Results
Compared to baseline, leukocytosis (p=0.019), neutrophilia (p<0.001), lymphopenia (p<0.001) and eosinopenia (p=0.008) were observed after only smoking. Endothelial as well as platelet-, monocyte- and leukocyte-derived microparticles (p<0.001 each) were elevated. In monocytes, mRNA expression of interleukin-6 (2.6±0.57-fold), tumor necrosis factor alpha (2.2±0.62-fold), and interleukin-1b (2.3±0.44-fold) were up-regulated as was interleukin-6 (1.2±0.12-fold) protein concentration in plasma. Smoking acutely inhibited mononuclear cell telomerase activity. Markers of endothelial damage, inflammation and cellular ageing were completely attenuated by red wine consumption.
Conclusion
Cigarette smoke results in acute endothelial damage, vascular as well as systemic inflammation and indicators of cellular ageing processes in otherwise healthy non-smokers. Pre-treatment with red wine was preventive. The findings underscore the magnitude of acute damage exerted by cigarette smoking in “occasional lifestyle smokers” and demonstrate the potential of red wine as a protective strategy to avert markers of vascular injury.
Red wine prevents the acute negative vascular effects of smoking. The American Journal of Medicine, 12 September 2016.
http://www.amjmed.com/article/S0002-9343(16)30912-3/pdf