Aspartam och försämrad glukostolerans

[King Grub]

This study examined whether sucrose, fructose, aspartame, and saccharin influences the association between obesity and glucose tolerance in 2856 adults from the NHANES III survey. Aspartame intake significantly influenced the association between body mass index (BMI) and glucose tolerance (interaction: P = 0.004), wherein only those reporting aspartame intake had a steeper positive association between BMI and glucose tolerance than those reporting no aspartame intake. Therefore, consumption of aspartame is associated with greater obesity-related impairments in glucose tolerance.

Appl Physiol Nutr Metab. 2016 May 24:1-4. Aspartame intake is associated with greater glucose intolerance in individuals with obesity.

http://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2015-0675#.V0VidcvoumQ

[WilsonTaylor]

Nu är ju jag bara amatör inom ämnet, men har inte detta diskuterats tidigare, att drycker med aspartam dricks av folk som redan är överviktiga, eller tror att det balanserar en i övrigt onyttig diet?

[King Grub]

Nu är ju jag bara amatör inom ämnet, men har inte detta diskuterats tidigare, att drycker med aspartam dricks av folk som redan är överviktiga, eller tror att det balanserar en i övrigt onyttig diet?

Studiens huvudförfattare Jennifer K u k (ja) svarar dig:

It is possible that individuals with impaired glucose tolerance could be opting for artificial sweeteners to decrease their carbohydrate intake. However, our results were the same with and without individuals with diabetes. Further, these observations were not seen with fasting glucose. As OGTTs are not commonly done in individuals without elevated fasting glucose, it is unlikely that these individuals would know to change their diet. Finally, given that there are studies that report a possible physiological rationale for our observation, we thought that our interpretation may be more likely.

Our conclusion that individuals who consume aspartame and have obesity, have worse glucose tolerance is entirely consistent with the interpretation that there is a steeper positive slope. From the graph, you will see that the greater slope between BMI and glucose intolerance in aspartame consumers means that there is a higher glucose intolerance for only individuals with a higher BMI.