King Grub
2016-04-16, 07:47
Objective.
Glucagon-like peptide 1 (GLP-1), peptide YY (PYY3-36), ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have all been implicated in the pathogenesis of obesity. However, it is unknown whether they exhibit adaptive changes with respect to postprandial secretion to a sustained weight loss.
Design.
Prospective cohort study.
Methods.
Twenty healthy obese individuals obtained a 13 % weight loss by adhering to an 8 week very low-calorie diet. After weight loss participants entered a 52 weeks maintenance protocol. Plasma levels of GLP-1, PYY3-36, ghrelin, GIP and glucagon to a 600 kilocalorie meal were measured before weight loss, after weight loss and after one year of weight maintenance. Area under the curve (AUC) was calculated as total AUC (tAUC) and incremental AUC (iAUC).
Results.
Weight loss was successfully maintained for 52 weeks. iAUC for GLP-1 increased by 40 % after weight loss (p<0.05) and increasing to 65 % at week 52 (p=0.001). iAUC for PYY3-36 increased by 59% after weight loss, and tAUC for PYY3-36 increased by 14% at week 52 (p=0.004). tAUC for ghrelin increased by 23 % after weight loss (p<0.0001), but at week 52 the increase was reduced to 14 % compared to before weight loss (p=0.006). iAUC for GIP increased by 31% after weight loss (p=0.003), but returned to before weight loss levels at week 52. Glucagon levels were unaffected by weight loss.
Conclusions.
Meal responses of GLP-1 and PYY3-36 remained increased one year after weight maintenance, whereas ghrelin and GIP reverted towards before-weight loss values. Thus, an increase in appetite inhibitory mechanisms and a partly decrease in appetite stimulating mechanisms appear to contribute to successful long term weight loss maintenance.
Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY 3-36. EJE 14 March 2016.
http://www.eje-online.org/content/early/2016/03/14/EJE-15-1116.abstract
Glucagon-like peptide 1 (GLP-1), peptide YY (PYY3-36), ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon have all been implicated in the pathogenesis of obesity. However, it is unknown whether they exhibit adaptive changes with respect to postprandial secretion to a sustained weight loss.
Design.
Prospective cohort study.
Methods.
Twenty healthy obese individuals obtained a 13 % weight loss by adhering to an 8 week very low-calorie diet. After weight loss participants entered a 52 weeks maintenance protocol. Plasma levels of GLP-1, PYY3-36, ghrelin, GIP and glucagon to a 600 kilocalorie meal were measured before weight loss, after weight loss and after one year of weight maintenance. Area under the curve (AUC) was calculated as total AUC (tAUC) and incremental AUC (iAUC).
Results.
Weight loss was successfully maintained for 52 weeks. iAUC for GLP-1 increased by 40 % after weight loss (p<0.05) and increasing to 65 % at week 52 (p=0.001). iAUC for PYY3-36 increased by 59% after weight loss, and tAUC for PYY3-36 increased by 14% at week 52 (p=0.004). tAUC for ghrelin increased by 23 % after weight loss (p<0.0001), but at week 52 the increase was reduced to 14 % compared to before weight loss (p=0.006). iAUC for GIP increased by 31% after weight loss (p=0.003), but returned to before weight loss levels at week 52. Glucagon levels were unaffected by weight loss.
Conclusions.
Meal responses of GLP-1 and PYY3-36 remained increased one year after weight maintenance, whereas ghrelin and GIP reverted towards before-weight loss values. Thus, an increase in appetite inhibitory mechanisms and a partly decrease in appetite stimulating mechanisms appear to contribute to successful long term weight loss maintenance.
Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY 3-36. EJE 14 March 2016.
http://www.eje-online.org/content/early/2016/03/14/EJE-15-1116.abstract