Högfettkost ger cancerogena förändringar i tarmens celler

[King Grub]

Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem cells of the mammalian intestine. Mechanistically, a HFD induces a robust peroxisome proliferator-activated receptor delta (PPAR-δ) signature in intestinal stem cells and progenitor cells (non-intestinal stem cells), and pharmacological activation of PPAR-δ recapitulates the effects of a HFD on these cells. Like a HFD, ex vivo treatment of intestinal organoid cultures with fatty acid constituents of the HFD enhances the self-renewal potential of these organoid bodies in a PPAR-δ-dependent manner. Notably, HFD- and agonist-activated PPAR-δ signalling endow organoid-initiating capacity to progenitors, and enforced PPAR-δ signalling permits these progenitors to form in vivo tumours after loss of the tumour suppressor Apc. These findings highlight how diet-modulated PPAR-δ activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature 531, 53–58 (03 March 2016.

http://www.nature.com/nature/journal/v531/n7592/full/nature17173.html

Not only does the high-fat diet change the biology of stem cells, it also changes the biology of non-stem-cell populations, which collectively leads to an increase in tumor formation,” says Yilmaz, who is a Koch Institute member and a gastrointestinal pathologist at Massachusetts General Hospital.

http://wi.mit.edu/news/archive/2016/high-fat-diet-linked-intestinal-stem-cell-changes-increased-risk-cancer

[egg]

Det kan vara något för LCHFare att tänka på.

[Eljest]

Snälla Grub, skicka den till kostdoktorn.