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Visa fullständig version : Försämrad glukostolerans av vistelse i varm miljö


King Grub
2016-03-18, 08:39
A high demand on thermoregulatory processes may challenge homeostasis, particularly regarding glucose regulation. This has been understudied, although it might concern millions of humans. The objective of this project was to examine the isolated and combined effects of experimental short-term mild heat exposure and metabolic level on glycoregulation. Two experimental randomized crossover studies were conducted. Ten healthy young men participated in study A, which comprised four sessions in a fasting state at two metabolic levels (rest and exercise at 60% of maximal oxygen uptake for 40 minutes) in two environmental temperatures (warm: 31°C and control: 22°C). Each session ended with an ad libitum meal, resulting in similar energy intake across sessions. In study B, twelve healthy young men underwent two 3-hr oral glucose tolerance tests (OGTT) in warm and control environmental temperatures. Venous blood was sampled at several time points. In study A, repeated measure ANOVAs revealed higher postprandial serum glucose and insulin levels with heat exposure. Glycemia following the OGTT was higher in the warm temperature compared with control. The kinetics of the serum glucose response to the glucose load was also affected by the environmental temperature (temperature-by-time interaction, P = 0.030), with differences between the warm and control conditions evidenced up to 90 minutes after the glucose load (all P < 0.033). These studies provide evidence that heat exposure alters short-term glycoregulation. The implication of this environmental factor in the physiopathology of type 2 diabetes has yet to be investigated.

Clin Sci (Lond). 2016 Mar 15. Impaired glucose tolerance after brief heat exposure: a randomized crossover study in healthy young men.