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Visa fullständig version : Fett saktar inte ned aminosyreupptag eller minskar proteinsyntes efter proteinintag


King Grub
2015-12-29, 22:22
Background & Aim

Dietary protein digestion and absorption plays an important role in modulating postprandial muscle protein synthesis. The impact of co-ingesting other macronutrients with dietary protein on protein digestion and absorption and the subsequent muscle protein synthetic response remains largely unexplored. This study investigated the impact of co-ingesting milk fat with micellar casein on dietary protein-derived amino acid appearance in the circulation and the subsequent postprandial muscle protein synthetic response in healthy older men.

Methods

Twenty-four healthy, older males (age: 65±1 y, BMI: 25.7±0.5 kg/m2) received a primed continuous infusion of L-[ring-2H5]-phenylalanine and L-[1-13C]-leucine and ingested 20 g intrinsically L-[1-13C]-phenylalanine and L-[1-13C]-leucine-labeled casein with (PRO+FAT; n=12) or without (PRO; n=12) 26.7 g milk fat. Plasma samples and muscle biopsies were collected in both the postabsorptive and postprandial state.

Results

Release of dietary protein-derived phenylalanine in plasma increased following protein ingestion (P<0.001) and tended to be higher in PRO compared with PRO+FAT (Time×Treatment P=0.076). No differences were observed in dietary protein-derived plasma phenylalanine availability (52±2 vs 52±3% in PRO vs PRO+FAT, respectively; P=0.868). Myofibrillar protein synthesis rates did not differ between treatments, calculated using either the L-[ring-2H5]-phenylalanine (0.036±0.003 vs 0.036±0.004 %/h after PRO vs PRO+FAT, respectively; P=0.933) or L-[1-13C]-leucine (0.051±0.004 vs 0.046±0.004 %/h, respectively; P=0.480) tracers. In accordance, no differences were observed in myofibrillar protein-bound L-[1-13C]-phenylalanine enrichments between treatments (0.018±0.002 vs 0.014±0.001 MPE, respectively; P=0.173).

Conclusion

Co-ingesting milk fat with micellar casein does not impair protein-derived phenylalanine appearance in the circulation and does not modulate postprandial myofibrillar protein synthesis rates.

Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men. Clinical Nutrition 23 December 2015.

exevision
2016-01-04, 19:19
Varför gör det inte det?

LillisJ
2016-01-04, 19:50
Skönt, en mindre optinoja :D

Sverker
2016-01-04, 19:51
Antagligen för att man undersökte kasein som är långsamt.
Antar att man får en tydlig separering i magsäcken mellan proteinet och fettet och det ena inte påverkar det andra när det gäller tömningen av magsäcken. Men det är bara spekulation.

Klein
2016-01-04, 22:19
Ganska säker på det skrivits på detta forum för ett antal år sedan att mjölkfett inte bromsar upptaget av vassleprotein men hittar dock inte ursprungsposten av King Grub eller någon studie för den delen.

Hel mjölk verkar iaf stimulera proteinsyntesen bättre än avfettad mjölk efter träning:

Kevin Tipton, Robert Wolfe; Med Sci Sports Exerc. 2006 Apr;38(4):667-74. Milk Ingestion Stimulates Net Muscle Protein Synthesis following Resistance Exercise.