King Grub
2015-12-07, 08:45
SCOPE:
Enhanced adiposity and metabolic inflammation are major features of obesity that could be impacted by dietary emulsifiers. We investigated in high-fat fed mice the effects using a new polar lipid emulsifier from milk (MPL) instead of soybean lecithin (SPL) on adipose tissue and intestinal mucosa function.
METHODS AND RESULTS:
Four groups of C57BL6 mice received for 8 weeks a low-fat diet (LF) or a high-fat diet devoid of polar lipids (HF) or a high-fat diet including MPL (HF-MPL) or SPL (HF-SPL). Compared with HF diet, HF-SPL diet increased white adipose tissue (WAT) mass (P<0.05), with larger adipocytes (P<0.05) and increased expression of MCP-1, LBP and leptin (P<0.05). This was not observed with HF-MPL diet despite similar dietary intakes and increased expression of FATP4 and MTTP, involved in lipid absorption, in upper intestine (P<0.05). HFP-MPL mice had a lower expression in WAT of CD68, marker of macrophage infiltration, vs HF and HFP-SPL mice (P<0.05), and more goblet cells in the colon (P<0.05).
CONCLUSIONS:
Unlike SPL, MPL in a high fat diet did not induce WAT hypertrophy and inflammation but increased colonic goblet cells. This supports further clinical exploration of different sources of dietary emulsifiers in the frame of obesity outbreak.
Mol Nutr Food Res. 2015 Nov 23. Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice.
Enhanced adiposity and metabolic inflammation are major features of obesity that could be impacted by dietary emulsifiers. We investigated in high-fat fed mice the effects using a new polar lipid emulsifier from milk (MPL) instead of soybean lecithin (SPL) on adipose tissue and intestinal mucosa function.
METHODS AND RESULTS:
Four groups of C57BL6 mice received for 8 weeks a low-fat diet (LF) or a high-fat diet devoid of polar lipids (HF) or a high-fat diet including MPL (HF-MPL) or SPL (HF-SPL). Compared with HF diet, HF-SPL diet increased white adipose tissue (WAT) mass (P<0.05), with larger adipocytes (P<0.05) and increased expression of MCP-1, LBP and leptin (P<0.05). This was not observed with HF-MPL diet despite similar dietary intakes and increased expression of FATP4 and MTTP, involved in lipid absorption, in upper intestine (P<0.05). HFP-MPL mice had a lower expression in WAT of CD68, marker of macrophage infiltration, vs HF and HFP-SPL mice (P<0.05), and more goblet cells in the colon (P<0.05).
CONCLUSIONS:
Unlike SPL, MPL in a high fat diet did not induce WAT hypertrophy and inflammation but increased colonic goblet cells. This supports further clinical exploration of different sources of dietary emulsifiers in the frame of obesity outbreak.
Mol Nutr Food Res. 2015 Nov 23. Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice.