Effekt av träning på telomerlängd senare i livet

[King Grub]

Physical activity and sports have repeatedly been reported to be associated with telomere length. We studied the association of different types of sports across different stages of life on relative leukocyte telomere length (rLTL) in advanced age.815 participants (397 men) from the Berlin Aging Study II aged over 61 years were included in the analysis. rLTL was measured by real time PCR and physical activity was determined retrospectively by questionnaire, assessing type and duration of sports in the past as well as currently. Five separate multiple linear regression models adjusted for various control variables were performed. 67.3% of participants exercised currently, whereas 19.4% performed sports only between the age of 20 and 30. rLTL was higher in subjects who stated to exercise currently (N = 456), and in subjects who engaged in endurance (N = 138) or intensive activity sports (N = 32). Current physical activity was positively associated with rLTL in the risk factor adjusted regression model (β = 0.26, p < 0.001) and practicing sports for a minimum of 10 years preceding the assessment had a significant effect on rLTL (β = 0.39, p = 0.011). The highest impact was seen for intensive activity sports (β = 0.79, p < 0.001) and physical activity since at least 42 years (β = 0.47, p = 0.001). However, physical activity only between 20 and 30 years of age did not affect rLTL in old age when compared to no sports at all (β = -0.16, p = 0.21). Physical activity is clearly associated with longer rLTL. The effect is seen with longer periods of physical activity (at least 10 years), with intensive sports activities having the greatest impact on rLTL. Our data suggest that regular physical activity for at least 10 years is necessary to achieve a sustained effect on rLTL.

PLoS One. 2015 Dec 2;10(12):e0142131. Sports and Exercise at Different Ages and Leukocyte Telomere Length in Later Life - Data from the Berlin Aging Study II (BASE-II).

[Blaine]

Låter bra! Har läst mycket om telomerer och att fysisk träning har gynnsam effekt är betryggande.

[Pherall]

På ämnet! Hittar dock inte länken till studien.



Vitamin D and its role in telomere length
A large epidemiological study consisting of 2,100 female twin pairs found that increased vitamin D levels correlated with increased telomere length in white blood cells (WBCs).10 Here’s the real kicker: the difference in telomere length between those with high (vitamin D sufficient) versus low (vitamin D insufficient) levels of vitamin D corresponded to 5 years of
 aging.10 The study also found that the participants that regularly supplemented vitamin D also had longer telomeres than those not taking supplements.10 Another study that included both males and females, again found that higher plasma vitamin D was significantly associated with longer telomere length in WBCs.11"

"A recent study found that individuals in the highest quartile of serum vitamin D had the longest lifespan compared to those in the lowest quartile.15 If we look at the optimal vitamin D range, “the vitamin D sweet spot,” it tends to be between 40-60 ng/ml.15 For these reasons your vitamin D levels can almost be thought of as a biomarker for aging"

[King Grub]

På ämnet! Hittar dock inte länken till studien.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676154/

[Pherall]

Man tackar!