King Grub
2015-11-11, 10:05
Energy drink consumption has been associated with serious cardiovascular events,1- 4 possibly related to caffeine and other stimulants. We hypothesized that drinking a commercially available energy drink compared with a placebo drink increases blood pressure and heart rate in healthy adults at rest and in response to mental and physical stress (primary outcomes). Furthermore, we hypothesized that these hemodynamic changes are associated with sympathetic activation, which could predispose to increased cardiovascular risk (secondary outcomes).
We studied 25 healthy participants (14 men) with a mean age of 29 years (95% CI, 26-31 years) and a mean body mass index of 25 (calculated as weight in kilograms divided by height in meters squared; 95% CI, 23-26). One participant did not complete 1 study day. Caffeine levels remained unchanged after the placebo drink, but increased significantly after energy drink consumption. Glucose levels increased similarly between the groups.
Baseline blood pressure and heart rate were normal and similar for participants on both the energy drink and placebo study days. Consumption of the energy drink elicited a 6.2% (95% CI, 4.5% to 7.8%) increase in systolic blood pressure (from 108.4 mm Hg to 115.0 mm Hg) vs a 3.1% (95% CI, 1.5% to 4.7%) increase with the placebo drink (from 108.3 mm Hg to 111.6 mm Hg) (P = .01). Diastolic blood pressure increased by 6.8% (95% CI, 4.1% to 9.6%) vs 0% (95% CI, −2.8% to 2.8%) with placebo (P = .001). Mean blood pressure increased after consumption of the energy drink by 6.4% (95% CI, 4.3% to 8.6%) from 74.2 mm Hg to 78.9 mm Hg vs by 1.0% (95% CI, −1.2% to 3.2%) with the placebo drink (from 74.9 mm Hg to 75.4 mm Hg) (P < .001). There was no significant difference in heart rate increase between the 2 groups. The energy drink did not further potentiate hemodynamic responses to any stress stimuli.
In this pilot study, a commercially available energy drink significantly increased levels of blood pressure and catecholamines in young healthy adults. Physical, mental, or cold stress did not further accentuate the blood pressure increase. These acute hemodynamic and adrenergic changes may predispose to increased cardiovascular risk.
A Randomized Trial of Cardiovascular Responses to Energy Drink Consumption in Healthy Adults. JAMA November 08, 2015.
http://jama.jamanetwork.com/article.aspx?articleid=2469194
We studied 25 healthy participants (14 men) with a mean age of 29 years (95% CI, 26-31 years) and a mean body mass index of 25 (calculated as weight in kilograms divided by height in meters squared; 95% CI, 23-26). One participant did not complete 1 study day. Caffeine levels remained unchanged after the placebo drink, but increased significantly after energy drink consumption. Glucose levels increased similarly between the groups.
Baseline blood pressure and heart rate were normal and similar for participants on both the energy drink and placebo study days. Consumption of the energy drink elicited a 6.2% (95% CI, 4.5% to 7.8%) increase in systolic blood pressure (from 108.4 mm Hg to 115.0 mm Hg) vs a 3.1% (95% CI, 1.5% to 4.7%) increase with the placebo drink (from 108.3 mm Hg to 111.6 mm Hg) (P = .01). Diastolic blood pressure increased by 6.8% (95% CI, 4.1% to 9.6%) vs 0% (95% CI, −2.8% to 2.8%) with placebo (P = .001). Mean blood pressure increased after consumption of the energy drink by 6.4% (95% CI, 4.3% to 8.6%) from 74.2 mm Hg to 78.9 mm Hg vs by 1.0% (95% CI, −1.2% to 3.2%) with the placebo drink (from 74.9 mm Hg to 75.4 mm Hg) (P < .001). There was no significant difference in heart rate increase between the 2 groups. The energy drink did not further potentiate hemodynamic responses to any stress stimuli.
In this pilot study, a commercially available energy drink significantly increased levels of blood pressure and catecholamines in young healthy adults. Physical, mental, or cold stress did not further accentuate the blood pressure increase. These acute hemodynamic and adrenergic changes may predispose to increased cardiovascular risk.
A Randomized Trial of Cardiovascular Responses to Energy Drink Consumption in Healthy Adults. JAMA November 08, 2015.
http://jama.jamanetwork.com/article.aspx?articleid=2469194