King Grub
2015-06-06, 10:28
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The purpose of this study was to examine the effect of chronic alcohol intake on the androgen receptor content (AR) in skeletal muscle, and to determine the resistance training (RT) influence.
METHODS
Forty-two 8-month-old male Sprague Dawley® rats (456±1 g; mean±SE) were divided into 5 groups: Baseline (B) (n=8), Sham exercise-Alcohol diet (Sham-Al) (n=8), Sham exercise-Normal diet (Sham-Nml) (n=8), Exercise-Alcohol diet (Ex-Al) (n=10), and Exercise-Normal diet (n=8). Both exercise groups underwent a 6-week “squat” RT protocol. The RT protocol was performed 3 times a week and consisted of 30 repetitions with a load increasing from 20% of body weight (BW) in the first week to 120% BW in the last week of the 6-week training period. The alcohol groups received an alcohol rich diet, in which ethanol provided 35 % of total caloric intake, throughout the 6-week period. B animals served as a pre-treatment control and were sacrificed at the onset of the 6-week training period.
RESULTS
The RT groups had significantly lower BW compared to the non-RT groups. However, no differences in muscle weights were found between RT and non-RT groups. Western blot analysis showed that for the rectus femoris, alcohol caused a significant decline in AR (p < 0.05). The AR of the soleus was significantly higher for the Ex-Nml group compared to the Ex-Al (p < 0.05). No effect of alcohol or resistance training was found for AR of the extensor digitorum longus. There were no differences in AR between B and Sham-Nml for any of the muscles examined.
CONCLUSION
Chronic alcohol intake caused a reduction in the AR of the type-II- fiber predominant rectus femoris; this reduction was not attenuated by RT. The AR of the type I-fiber-predominant soleus was not affected by chronic alcohol intake alone; however, the RT-induced increase in the AR was prevented by chronic alcohol intake
Chronic Alcohol Intake And Resistance Training On Skeletal Muscle Androgen Receptor Protein Content In Rats. Medicine & Science in Sports & Exercise 37.5 (2005): S238.
http://www.researchgate.net/profile/Lymperis_Koziris/publication/246519011_Chronic_Alcohol_Intake_And_Resistance_Tr aining_On_Skeletal_Muscle_Androgen_Receptor_Protei n_Content_In_Rats_1241_Board_96_330_PM_-_500_PM/links/55550c1708ae6fd2d821bc4b.pdf
The purpose of this study was to examine the effect of chronic alcohol intake on the androgen receptor content (AR) in skeletal muscle, and to determine the resistance training (RT) influence.
METHODS
Forty-two 8-month-old male Sprague Dawley® rats (456±1 g; mean±SE) were divided into 5 groups: Baseline (B) (n=8), Sham exercise-Alcohol diet (Sham-Al) (n=8), Sham exercise-Normal diet (Sham-Nml) (n=8), Exercise-Alcohol diet (Ex-Al) (n=10), and Exercise-Normal diet (n=8). Both exercise groups underwent a 6-week “squat” RT protocol. The RT protocol was performed 3 times a week and consisted of 30 repetitions with a load increasing from 20% of body weight (BW) in the first week to 120% BW in the last week of the 6-week training period. The alcohol groups received an alcohol rich diet, in which ethanol provided 35 % of total caloric intake, throughout the 6-week period. B animals served as a pre-treatment control and were sacrificed at the onset of the 6-week training period.
RESULTS
The RT groups had significantly lower BW compared to the non-RT groups. However, no differences in muscle weights were found between RT and non-RT groups. Western blot analysis showed that for the rectus femoris, alcohol caused a significant decline in AR (p < 0.05). The AR of the soleus was significantly higher for the Ex-Nml group compared to the Ex-Al (p < 0.05). No effect of alcohol or resistance training was found for AR of the extensor digitorum longus. There were no differences in AR between B and Sham-Nml for any of the muscles examined.
CONCLUSION
Chronic alcohol intake caused a reduction in the AR of the type-II- fiber predominant rectus femoris; this reduction was not attenuated by RT. The AR of the type I-fiber-predominant soleus was not affected by chronic alcohol intake alone; however, the RT-induced increase in the AR was prevented by chronic alcohol intake
Chronic Alcohol Intake And Resistance Training On Skeletal Muscle Androgen Receptor Protein Content In Rats. Medicine & Science in Sports & Exercise 37.5 (2005): S238.
http://www.researchgate.net/profile/Lymperis_Koziris/publication/246519011_Chronic_Alcohol_Intake_And_Resistance_Tr aining_On_Skeletal_Muscle_Androgen_Receptor_Protei n_Content_In_Rats_1241_Board_96_330_PM_-_500_PM/links/55550c1708ae6fd2d821bc4b.pdf