Hälsopåverkan på fostret av aspartamintag under graviditet

[King Grub]

The use of artificial sweeteners has increased together with the epidemic growth of obesity. In addition to their widespread use in sodas, artificial sweeteners are added to nearly 6,000 other products sold in the US, including baby foods, frozen dinners and even yogurts. It has been suggested that the use of nonnutritive sweeteners can lead to body weight gain and an altered metabolic profile. However, very few studies have evaluated the effects of maternal consumption of artificial non-caloric sweeteners on body weight, feeding behavior or the metabolism of offspring in adult life. In this study, we found that animals exposed to aspartame during the prenatal period presented a higher consumption of sweet foods during adulthood and a greater susceptibility to alterations in metabolic parameters, such as increased glucose, LDL and triglycerides. These effects were observed in both males and females, although they were more pronounced in males. Despite the preliminary nature of this study, and the need for further confirmation of these effects, our data suggest that the consumption of sweeteners during gestation may have deleterious long-term effects and should be used with caution.

Appetite. 2014 Dec 24. pii: S0195-6663(14)00774-0. Metabolic and feeding behavior alterations provoked by prenatal exposure to aspartame.

[cero]

we found that animals exposed to aspartame during the prenatal period presented a higher consumption of sweet foods during adulthood and a greater susceptibility to alterations in metabolic parameters, such as increased glucose, LDL and triglycerides.

Vad kan mekanismerna vara bakom dessa?

[RobinEH]

Vad kan mekanismerna vara bakom dessa?

Fördelen med att studera på universitet.
...Despite the fact that aspartame is usually completely hydrolyzed (Rycerz and Jaworska-Adamu, 2013), when pregnant animals are subjected to chronic, high levels of this sweetener, some may reach the fetus. In animals that were subjected to aspartame throughout their prenatal development, their ability to activate the post-ingestive factor of the food reward pathway may be affected, or underdeveloped, losing, at least in part, this hypothalamic control of food ingestion, especially concerning sweet foods...
...It is generally agreed that Phe is actively transported across the placenta (Pueschel, Boylan, Jackson & Piasecki, 1982), resulting in an increase in placental Phe dependent on maternal consumption. In rodents, high levels of accumulated Phe may be converted into other metabolites (Scriver et al, 1995*andGazit et al, 1998) that could interfere with normal metabolism (Gazit et al, 1998*andGazit et al, 2003). In rodents, phenylalanine hydroxylase activity is absent until the end of gestation (Tourian et al, 1972*and*Yeoh et al, 1988). It is improbable that the concentration of phenylalanine in the brains of offspring is as high as that found in hyperphenylalaninemia, but a small chronic alteration in neuronal glucose homeostasis during prenatal development could lead to permanent changes in this parameter...

[3bz]

"In rodents, phenylalanine hydroxylase activity is absent until the end of gestation..."

Fast nu verkar det ju inte vara så (http://www.ncbi.nlm.nih.gov/pubmed/3186165) hos människor.