Jishuku
2014-06-15, 22:52
Hittade precis denna studie. Tolkar jag det rätt om jag säger att det är en dålig idé att använda ALA under en period där man ligger på kaloriöverskott, men kanske en bra idé om man gör det när man ligger på underskott/fastar?
En person på Longecity som har tillgång till hela studien skrev att effekten varade upp till ett helt år efter att man slutat använda ALA.
Merry BJ, Kirk AJ, Goyns MH.
Dietary lipoic acid supplementation can mimic or block the effect of dietary
restriction on life span.
Mech Ageing Dev. 2008 Apr 22;129(6):341-348. [Epub ahead of print]
PMID: 18486188
Abstract
Dietary restriction feeding extends survival in a range of species but a
detailed understanding of the underlying mechanism is lacking. There is
interest therefore in identifying a more targeted approach to replicate this
effect on survival.
We report that in rats dietary supplementation with alpha-lipoic acid, has
markedly differing effects on lifetime survival depending upon the dietary
history of the animal. When animals are switched from DR feeding to ad
libitum feeding with a diet supplemented with alpha-lipoic acid, the
extended survival characteristic of DR feeding is maintained, even though
the animals show accelerated growth. Conversely, switching from ad libitum
feeding a diet supplemented with alpha-lipoic acid to DR feeding of the
non-supplemented diet, blocks the normal effect of DR to extend survival,
even after cessation of lipoic acid supplementation. Unlike the dynamic
effect of switching between DR and ad libitum feeding with a
non-supplemented diet where the subsequent survival trajectory is determined
by the new feeding regime, lipoic acid fixes the survival trajectory to that
established by the initial feeding regime.
Ad libitum feeding a diet supplemented with lipoic acid can therefore act as
mimetic of DR to extend survival.
En person på Longecity som har tillgång till hela studien skrev att effekten varade upp till ett helt år efter att man slutat använda ALA.
Merry BJ, Kirk AJ, Goyns MH.
Dietary lipoic acid supplementation can mimic or block the effect of dietary
restriction on life span.
Mech Ageing Dev. 2008 Apr 22;129(6):341-348. [Epub ahead of print]
PMID: 18486188
Abstract
Dietary restriction feeding extends survival in a range of species but a
detailed understanding of the underlying mechanism is lacking. There is
interest therefore in identifying a more targeted approach to replicate this
effect on survival.
We report that in rats dietary supplementation with alpha-lipoic acid, has
markedly differing effects on lifetime survival depending upon the dietary
history of the animal. When animals are switched from DR feeding to ad
libitum feeding with a diet supplemented with alpha-lipoic acid, the
extended survival characteristic of DR feeding is maintained, even though
the animals show accelerated growth. Conversely, switching from ad libitum
feeding a diet supplemented with alpha-lipoic acid to DR feeding of the
non-supplemented diet, blocks the normal effect of DR to extend survival,
even after cessation of lipoic acid supplementation. Unlike the dynamic
effect of switching between DR and ad libitum feeding with a
non-supplemented diet where the subsequent survival trajectory is determined
by the new feeding regime, lipoic acid fixes the survival trajectory to that
established by the initial feeding regime.
Ad libitum feeding a diet supplemented with lipoic acid can therefore act as
mimetic of DR to extend survival.