King Grub
2014-06-12, 07:09
Introduction:
We investigated the effect of resistance exercise intensity and exercise-induced metabolic stress on the activation of anabolic signaling and expression of myogenic genes in skeletal muscle.
Methods:
10 strength-trained athletes performed high-intensity [HI, 74% of 1 repetition maximum (RM)], middle-intensity (MI, 54% 1RM), or middle-intensity (54% 1RM) no-relaxation exercise (MIR). Kinase phosphorylation level and myogenic gene expression in muscle samples were evaluated before, 45 min, 5h, and 20 h after exercise.
Results:
The lactate concentration in MI was approximately 2-fold lower than in the 2 other sessions, and it was highest in MIR. The phosphorylation level of extracellular kinase 1/2Thr202/Tyr204 after exercise was related to metabolic stress. Metabolic stress induced a decrease in myostatin mRNA expression, whereas mechano-growth factor mRNA level depended on exercise intensity.
Conclusion:
This study demonstrates that both intensity and exercise-induced metabolic stress can be manipulated to affect muscle anabolic signaling
Muscle Nerve. 2014 Jun 11. The Influence of Resistance Exercise Intensity and Metabolic Stress on Anabolic Signaling and the Expression of Myogenic Genes in Skeletal Muscle.
We investigated the effect of resistance exercise intensity and exercise-induced metabolic stress on the activation of anabolic signaling and expression of myogenic genes in skeletal muscle.
Methods:
10 strength-trained athletes performed high-intensity [HI, 74% of 1 repetition maximum (RM)], middle-intensity (MI, 54% 1RM), or middle-intensity (54% 1RM) no-relaxation exercise (MIR). Kinase phosphorylation level and myogenic gene expression in muscle samples were evaluated before, 45 min, 5h, and 20 h after exercise.
Results:
The lactate concentration in MI was approximately 2-fold lower than in the 2 other sessions, and it was highest in MIR. The phosphorylation level of extracellular kinase 1/2Thr202/Tyr204 after exercise was related to metabolic stress. Metabolic stress induced a decrease in myostatin mRNA expression, whereas mechano-growth factor mRNA level depended on exercise intensity.
Conclusion:
This study demonstrates that both intensity and exercise-induced metabolic stress can be manipulated to affect muscle anabolic signaling
Muscle Nerve. 2014 Jun 11. The Influence of Resistance Exercise Intensity and Metabolic Stress on Anabolic Signaling and the Expression of Myogenic Genes in Skeletal Muscle.